LEFKOWITZ LAB

Staus, D.P., Strachan, R.T., Manglik, A., Pani, Biswarajan, Kahsai, A.W., Tae Hun Kim, Wingler, L.M., Ahn, S., Chatterjee, A., Masoudi, A., Kruse, A.C., Pardon, E., Steyaert, J., Weis, W.I., Prosser, Scott, R., Kobilka, B.K., Costa, T. and Lefkowitz, R.J.  Allosteric Nanobodies Reveal the Dynamic Range and Diverse Mechanisms of GPCR Activation.  Nature, in press, 2016..


Thomsen, A.R.B., Plouffe, B., Cahill III, T.J., Shukla, A.K., Tarrasch, J.T., Dosey, A.M., Kahsai, A.W., Strachan, R.T., Pani, B., Mahoney, J.P., Huang, L., Breton, B., Sunahara, R.K., Skiniotis, G., Bouvier, M. and Lefkowitz, R.J. GPCR-G protein-β-arrestin super-complex mediates sustained G protein signaling. Cell, in press, 2016.


Kahsai, A.W., Wisler, J.W., Lee, J., Ahn, S. Cahill, T.J., Dennison, S.M., Staus, D.P., Thomsen, A.R.B., Anasti, K.M., Pani, B., Wingler, L.M., Desai, H., Bompiani, D.M., Strachan, R.T., Qin, X., Alam, S.M., Sullenger, B.A. and Lefkowitz, R.J.  Conformationally Selective RNA Aptamers Allosterically Modulate the β2-Adrenergic Receptor.  Nature Chem. Biol., in press, 2016.


Lefkowitz. R.J.  Inspiring the next generation of physician-scientists.  Journal of Clinical Investigation 125: 2905-2907, 2015.


Wisler, J.W., Harris, E.M., Rasich, M.C., Mao, L., Kim, J., Rockman, H.W. and Lefkowitz, R.J.  The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a muring model of Marfan Syndrome.  American Journal of Physiology  309; H1516-H1527, 2015.


Lefkowitz, R.J.  A Brief History of G-protein coupled receptors (Nobel Lecture).
Angew Chem Int Ed Engl. 25: 6366-6378, 2013.  PMID23650015.


Tang, W., Strachan, R.T., Lefkowitz, R.J. and Rockman, H.A.  Allosteric Modulation of β-Arrestin-Biased AT1R Signaling by Membrane Stretch.  J. Biol. Chem. 289: 28271-28283, 2014. PMCID:PMC4192482


Shukla, A.K., Westfield, G.H., Xiao, K., Reis, R.I., Huang, L-Y., Tripathi-Shukla, P., Qian, J., Li, Sheng, Blanc, A., Oleskie, A.N., Dosey, A.M., Su, M., Liang, C-R., Gu, L-L., Shan, J-M., Chen, X., Hanna, R., Choi, M., Yao, X.J., Klink, B.U., Kahsai, A.W. Sidhu, S.S., Koide, S., Penczek, P.A., Kossiakoff, A.A., Woods, V.L., Kobilka, B.K., Skiniotis, G. and Lefkowitz, R.J.  Visualization of arrestin recruitment by a G-protein-coupled receptor.  Nature 512: 218-234, 2014. PMCID: PMC4134437.


Staus, D. P., Wingler, L.M., Strachan, R.T., Rasmussen, S.G.F., Pardon, E., Ahn, S., Steyaert, J., Kobilka, B.K. and Lefkowitz, R.J.  Regulation of β2-Adrenergic Receptor Function by Conformationally Selective Single-Domain Intrabodies.  Molecular Pharmacology 85: 472-481, 2014. PMCID: PMC3935154.


Strachan, R.T., Sun, J-P, Rominger, D.H., Violin, J.D., Ahn, S., Thomsen, A.R., Xu, X., Kleist, A., Costa, T. and Lefkowitz, R.J.  Divergent Transducer-Specific Molecular Efficacies Generate Biased Agonism at a G Protein-Coupled Receptor (GPCR).  J. Biol. Chem. 289: 14211-14224, 2014. PMCID:PMC4022887.


Wisler, J.W., Xiao, K., Thomsen, A.R.B. and Lefkowitz, R.J.  Recent developments in biased agonism.  Current Opinion in Cell Biology 27:18-24, 2013.  PMCID:PMC3971386


Simard, E., Kovacs, J.J., Miller, W.E., Kim, J., Grandbois, M. and Lefkowitz, R.J. β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration.  PLOS ONE 8, 1-14, 2013. PMCID: PMC3821855.


Aristotelous, T., Ahn, S., Shukla, A.K., Gawron, S., Sassano, M.F., Kahsai, A.W., Wingler, L.M., Zhu, X., Tripathi-Shukla, P., Huang, X-P., Riley, J., Besnard, J., Read, K.D., Roth, B.., Gilbert, I.H., Hopkins, A.L., Lefkowitz, R.J. and Navratilova, I.  Discovery of β-2-Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor.  ACS Medicinal Chemistry Letters 4, 1005-1010, 2013. PMCID: PMC3892729.


Lefkowitz, R.J.  Arrestins Come of Age: A Personal Historical Perspective.  Progress in Molecular Biology and Translational Science 118, 3-18, 2013.  PMCID:PMC3654799


Shukla, A.K., Manglik, A., Kruse, A.C., Xiao, K., Reis, R.I., Tseng, Wei-Chou, Staus, D., Hilger, D., Uysal, S., Huang, L.Y., Paduch, M., Shukla, P.T., Koide, A., Kide, S., Weis, W.I., Kossiakoff, A.A., Kobilka, B.K. and Lefkowitz, R.J.  Structure of active β-arrestin 1 bound to a G protein-coupled receptor phosphopeptide.  Nature 497, 137-142, 2013. PMCID: PMC3654799.


Weiss, D.R., Ahn, S.K., Sassano, M.F., Kleist, A., Zhu, X., Strachan, R., Roth, B.L., Lefkowitz, R.J. and Shoichet, B.K.  Conformation guides molecular efficacy in docking screens of activated β2-adrenergic G protein coupled receptor. ACS Chemical Biology 8, 1018-1026, 2013. PMCID: PMC3658555


Hara, M.R., Sachs, B.D., Caron, M.G. and Lefkowitz, R.J.  Pharmacological blockade of a β2AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model.  Cell Cycle, 12, 219-224, 2013. PMCID:PMC3575451.