1. Lefkowitz, R.J., Roth, J., Pricer, W. and Pastan, I. ACTH receptors in the adrenal: Specific binding of ACTH-125I and relation to adenyl cyclase. Proc. Natl. Acad. Sci. 65, 745-752, 1970.
2. Lefkowitz, R.J. Specific binding of ACTH-125I by adrenal cyclase preparations. Proc. Fogarty Inter'l. Center Colloquim on the Biological Role of Adenyl Cyclase and Cyclic AMP, 1969.
3. Lefkowitz, R.J., Roth J., Pricer, W. and Pastan, I. Radioreceptor assay of adrenocorticotropic hormone: New approach to assay of polypeptide hormones in plasma. Science 170: 633-635, 1970.
4. Lefkowitz, R.J., Roth J. and Pastan, I. Effects of calcium on ACTH stimulation of the adrenal: Separation of hormone binding from adenyl cyclase activity. Nature 228: 864-866, 1970.
5. Lefkowitz, R.J., Roth J. and Pastan, I. ACTH-receptor interaction in the adrenal: A model for the first step in the action of hormones which stimulate adenyl cyclase. Ann. of N.Y. Acad. Sci. 185: 195-209, 1971.
6. Lefkowitz, R.J., Roth, J. and Pastan, I. Radioreceptor assay of ACTH in Methods in Investigative and Diagnostic Endocrinology, (S.A. Berson and R.S. Yalow, eds.). North Holland Publishing Co., Amsterdam, 1972.
7. Lefkowitz, R.J. and Haber, E. A fraction of the ventricular myocardium that has the specificity of the cardiac beta-adrenergic receptor. Proc. Natl. Acad. Sci. 68: 1773-1777, 1971.
8. Roth, J., Pastan, I., Lefkowitz, R.J., Pricer, W., Freychet, P. and Nevil D. ACTH receptors in the adrenal and insulin receptors in liver in "Structure Activity Relationship of Protein and Polypeptide Hormones," (M. Margolis and F.C. Greenwood, eds.). Excerpta Medica, Amsterdam, p. 228, 1971.
9. Lefkowitz, R.J. Characterization and purification of the cardiac beta-adrenergic receptor in The Role of Membranes in Metabolic Regulation, (M. Mehlman, ed.). Academic Press, pp. 261-285, 1972.
10. Lefkowitz, R.J., Haber, E. and O'Hara, D. Identification of the cardiac beta-adrenergic receptor protein: Solubilization and purification by affinity chromatography. Proc. Natl. Acad. Sci. 69: 2828-2832, 1972.
11. Lefkowitz, R.J. and Levey, G.S. Norepinephrine: Dissociation of beta-receptor binding from adenylate cyclase activation in solubilized myocardium. Life Sci. 11: 821-828, 1972.
12. Lefkowitz, R.J., Sharp, G. and Haber, E. Specific binding of beta-adrenergic catecholamines to a subcellular fraction from cardiac muscle. J. Biol. Chem. 248: 342-349, 1973.
13. Lefkowitz, R.J. and Haber, E. Physiological receptors as physicochemical entities. Circ. Res. 32, Suppl. 1: 46-52, 1973.
14. Lefkowitz, R.J. Isolated hormone receptors: Physiological and clinical implications. New Engl. J. Med. 288: 1061-1066, 1973.
15. Lefkowitz, R.J. Isolated beta-adrenergic binding sites: Potential assay vehicle for measurement of catecholamines. Pharm. Revs. 25: 259-268, 1973.
16. Lefkowitz, R.J., O'Hara, D. and Warshaw, J. Binding of catecholamines to receptors in cultured myocardial cells. Nature, New Biology 244: 79-80, 1973.
17. Haber, E. and Lefkowitz, R.J. Isotopic displacement assays: The relative merits of antibodies and isolated physiological receptors in Diagnostic Nuclear Cardiology. C.V. Mosby Co., St. Louis, pp. 343-347, 1974.
18. Lefkowitz, R.J. Approaches to the measurement of catecholamines in plasma present and future in Diagnostic Nuclear Cardiology. C.V. Mosby Co., St. Louis, pp. 366-370, 1974.
19. Lefkowitz, R.J. Toward isolation of beta-adrenergic binding protein, in Frontiers in Catecholamine Research, (E. Usdin and S. Snyder, eds.). Pergamon Press, pp. 361-368, 1973.
20. O'Hara, D. and Lefkowitz, R.J. Agarose-norepinephrine derivatives for purification of adrenergic receptors and binding proteins in Methods of Enzymology Affinity Techniques, (S.P. Colowick and N.O. Kaplan, eds.). Academic Press, pp. 695-700, 1974.
21. Butcher, R.W., Crofford, O.B., Gammeltoff, S., Gliemann, J., Gavin, J.R., Goldfine, I., Kahn, R., Rodbell, M., Roth, Jr., Jarrett, L., Larner, J., Lefkowitz, R.J., Levine, R. and Marinetti, G.V. Insulin activity: The solid matrix. Science 182: 396-397, 1973.
22. Lefkowitz, R.J. Molecular pharmacology of beta-adrenergic receptors. Biochem. Pharmacol. 23: 2069-2076, 1974.
23. Lefkowitz, R.J., O'Hara, D. and Warshaw, J.B. Surface interaction of [3H]norepinephrine with cultured embryo myocardial cells. Biochem. Biophys. Acta 332: 317-328, 1974.
24. Lefkowitz, R.J. Selectivity in beta-adrenergic responses: Clinical implications. Circulation 44: 783-786, 1974.
25. Vatner, D. and Lefkowitz, R.J. [3H]Propranolol binding site in myocardial membranes: Non-identity with beta-adrenergic receptors. Mol. Pharmacol. 10: 450-456, 1974.
26. Lefkowitz, R.J. Catecholamine stimulated myocardial adenylate cyclase: Effects of phospholipase digestion and the role of membrane lipids. J. Mol. and Cell. Cardiol. 7: 27-37, 1975.
27. Caron, M.G. and Lefkowitz, R.J. Temperature immutability of adenylate cyclase-coupled beta-adrenergic receptors. Nature 249: 258-260, 1974.
28. Lefkowitz, R.J. Catecholamine stimulation of myocardial adenylate cyclase: Effects of nucleotides. J. Mol. and Cell. Cardiol. 7: 237-248, 1975.
29. Lefkowitz, R.J. Stimulation of catecholamine sensitive adenylate cyclase by 5'guanylyl imidodiphosphate. J. Biol. Chem. 249: 6119-6124, 1974.
30. Lefkowitz, R.J. [3H]Norepinephrine binding: Unrelated to catechol-o-methyl transferase. Biochem. Biophys. Res. Commun. 58: 1110-1118, 1974.
31. O'Keefe, D., Lefkowitz, R.J., Grantham, N.R., Beierholm, E.A. and Daggett, W.M. Effects of cardiac denervation and failure on canine myocardial norepinephrine binding sites. Cardiovasc. Res., Vol. IX, No. 2, pp. 219-223, 1975.
32. Lefkowitz, R.J. [3H]GTP binding sites in solubilized myocardium: Relation to adenylate cyclase. J. Biol. Chem. 250: 1006-1011, 1975.
33. Lefkowitz, R.J. Heterogeneity of adenylate cyclase-coupled beta-adrenergic receptors. Biochem. Pharmacol. 24: 583-590, 1975.
34. Lefkowitz, R.J., Mukherjee, C., Coverstone, M. and Caron, M.G. Stereospecific [3H] (-)alprenolol binding sites, beta-adrenergic receptors and adenylate cyclase. Biochem. Biophys. Res. Commun. 60: 703-709, 1974.
35. Limbird, L.E. and Lefkowitz, R.J. Myocardial guanylate cyclase: properties of the enzyme and effects of cholinergic agonists in vitro. Biochem. Biophys. Acta, Enzymology 377: 186-196, 1975.
36. Lefkowitz, R.J. Catecholamine sensitive adenylate cyclase: Biochemical model of beta-adrenergic receptors. Proceedings of 12th International Conference of International Medicine, 1975.
37. Lefkowitz, R.J. Biochemistry of beta-adrenergic receptor and adenylate cyclase. Proceedings of the 9th Meeting of the Federation of European Biochemistry Society, 1975.
38. Caron, M.G. and Lefkowitz, R.J. Beta-adrenergic receptors: Basic studies and clinical implications. Proceedings of the 1st International Asthma Conference in New Directions in Asthma (M.Stein, ed.). American College of Chest Physicians, Park Ridge, Ill. pp. 85-101, 1975.
39. Lefkowitz, R.J. Clinical pharmacology of beta-adrenergic blocking drugs. Medical Challenge 9: 72-76, 1977.
40. Aprille, J.R., Lefkowitz, R.J. and Warshaw, J.B. [3H]Norepinephrine binding and lipolysis by isolated fat cells. Biochem. Biophys. Acta 373: 502-513, 1974.
41. Lefkowitz, R.J. [3H](-)Alprenolol: New tool for the study of beta-adrenergic receptors in Methods in Receptor Research (M. Blecher, ed.). Marcel Dekker, Inc., New York.
42. Mukherjee, C., Caron, M.G., Coverstone, M. and Lefkowitz, R.J. Identification of beta-adrenergic receptors in frog erythrocyte membranes with [3H](-)alprenolol. J. Biol. Chem. 250: 4869-4875, 1975.
43. Lefkowitz, R.J. and Caron, M.G. Characteristics of 5'guanylyl- imidodiphosphate activated adenylate cyclase. J. Biol. Chem. 250: 4418-4423, 1975.
44. Lefkowitz, R.J. Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists. Biochem. Pharmacol. 24: 1651, 1975.
45. Lefkowitz, R.J., Caron, M.G., Limbird, L., Mukherjee, C. and Williams, L.T. Membrane bound hormone receptors in Membrane Bound Enzymes (A. Martinosi, ed.). Plenum Press, New York.
46. Alexander, R.W., Williams, L.T. and Lefkowitz, R.J. Identification of cardiac beta-adrenergic receptors by [3H](-)alprenolol binding. Proc. Natl. Acad. Sci. USA 72: 1564-1568, 1975.
47. Mukherjee, C., Caron, M.G. and Lefkowitz, R.J. Catecholamine induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptors. Proc. Natl. Acad. Sci. USA , 72:1945-1949, 1975.
48. Lefkowitz, R.J. Identification of beta-adrenergic receptors in Isolation of Hormone Receptors (G. Levey, ed.). Marcell Dekker, New York, 1975.
49. Limbird, L.E., DeMeyts, P. and Lefkowitz, R.J. Beta-adrenergic receptors: Evidence for negative cooperativity. Biochem. Biophys. Res. Commun. 64: 1160-1168, 1975.
50. Mickey, J.V., Tate, R. and Lefkowitz, R.J. Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (-)isoproterenol in vitro. J. Biol. Chem. 250: 5727-5729, 1975.
51. Lefkowitz, R.J., Caron, M.G. and Mukherjee, C. Identification and regulation of beta-adrenergic receptors in Proceedings of the 9th Miles International Symposium on Cell Surface Receptors, Raven Press, New York, 1975.
52. Mukherjee, C., Caron, M.G., Mullikin, D. and Lefkowitz, R.J. Structure activity relationship of beta-adrenergic receptors: Determination by direct binding studies. Mol. Pharmacol. 12: 16-31, 1976.
53. Lefkowitz, R.J. and Limbird, L.E. The beta-adrenergic receptor and adenylate cyclase. Biochimica et Biophysica Acta 457: 1-39, 1976.
54. Lefkowitz, R.J., Caron, M.G. and Mukherjee, C. Beta-adrenergic receptors: structure activity relations determined by direct binding studies in Receptors in Pharmacology (J. Smythies and R. Bradley, eds.). Marcel Dekker, Inc., New York, Vol. 11, pp. 97-121, 1978.
55. Limbird, L.E. and Lefkowitz, R.J. Adenylate cyclase-coupled beta-adrenergic receptors: Role of membrane lipids and other factors in receptor binding and enzyme stimulation by catecholamines. Mol. Pharmacol. 12: 559-567, 1976.
56. Williams, L.T., Snyderman, R. and Lefkowitz, R.J. Identification of beta-adrenergic receptors in human leukocytes with (-) [3H]alprenolol. J. Clin. Invest. 57: 149-155, 1976.
57. Zatz, M., Kebabian, J.W., Romero, J.A., Lefkowitz, R.J. and Axelrod, J. Pineal beta-adrenergic receptor: Correlation of binding of 3H-(1)-alprenolol with stimulation of adenylate cyclase. J. Pharmacol. Exp. Therap. 196: 714-722, 1976.
58. Alexander, R.W., Davis, J.N. and Lefkowitz, R.J. Direct identification of beta-adrenergic receptors in rat brain. Nature 258: 437, 1975.
59. Lefkowitz, R.J., Mukherjee, C., Caron, M.G., Limbird, L.E., Alexander, R.W., Williams, L.T., Mickey, J.V., Tate, R. Regulation of adenylate cyclase-coupled beta-adrenergic receptors. Recent Progress in Hormone Research 32: 597-632, 1976.
60. Limbird, L.E. and Lefkowitz, R.J. Biochemical and molecular characteristics of beta-adrenergic receptor binding sites in Proceedings of the Nato Advanced Study Institute on Surface Membrane Receptors, NATO ASI, Series, Vol. 11, pp. 387-404, Plenum Press, New York, 1976.
61. Williams, L.T., Jarett, L. and Lefkowitz, R.J. Adipocyte beta-adrenergic receptors: Identification and subcellular localization by (-)[3H]alprenolol binding. J. Biol. Chem. 251: 3096-3104, 1976.
62. Caron, M.G. and Lefkowitz, R.J. Solubilization and characterization of the beta-adrenergic receptor of frog erythrocytes. J. Biol. Chem. 251: 2374-2384, 1976.
63. Caron, M.G. and Lefkowitz, R.J. Solubilization of the beta-adrenergic receptor. Biochem. Biophys. Res. Commun. 68: 315, 1976.
64. Lefkowitz, R.J. The beta-adrenergic receptor, a mini review. Life Sci. 18: 461-472, 1976.
65. Lefkowitz, R.J. and Limbird, L.E. Biochemical techniques for the study of drug action. Progress in Cardiovascular Diseases, Vol. 18, pp. 309-321, 1976.
66. Mickey, J.V., Tate, R., Mullikin, D. and Lefkowitz, R.J. Characterization of catecholamine tolerance in vitro: Correlation between adenylate cyclase sensitivity and beta-adrenergic receptor binding. Mol. Pharmacol. 12: 409-419, 1976.
67. Davis, J.N., Miller, R.D. and Lefkowitz, R.J. A possible role for neurotransmitter receptors in stroke. Proc. of the Tenth Princeton Conference of Cerebrovascular Disease, 1976.
68. Mukherjee, C. and Lefkowitz, R.J. Desensitization of beta-adrenergic receptors by beta-adrenergic agonists in a cell-free system: Resensitization by 5'guanylylimidodiphosphate and other purine nucleotides. Proc. Natl. Acad. Sci. USA 73: 1494-1498, 1976.
69. Mukherjee, C., Caron, M.G. and Lefkowitz, R.J. Regulation of beta-adrenergic receptors by beta-adrenergic agonists in vivo. Endocrinology 99: 343-353, 1976.
70. Limbird, L. and Lefkowitz, R.J. Negative cooperativity among beta-adrenergic receptors of frog erythrocytes. J. Biol. Chem. 251: 5007-5014, 1976.
71. Williams, L.T. and Lefkowitz, R.J. Identification of alpha-adrenergic receptors by [H3]dihydroergocryptine binding. Science 192: 791-793, 1976.
72. Rudolph, S.A. and Lefkowitz, R.J. Receptors, cyclic nucleotides and transport, in Handbook of Transport (D. Tosteson, ed.), Springer-Verlag.
73. Lefkowitz, R.J., Mullikin, D. and Caron, M.G. Regulation of beta-adrenergic receptors by 5'guanylylimidodiphosphate and other purine nucleotides. J. Biol. Chem. 251: 4688-4692, 1976.
74. Lefkowitz, R.J. Identification and regulation of beta-adrenergic receptors in Hormone Receptors, (D. Klachko, L. Forte and J. Franz, eds.). Plenum Press, New York, Vol. 96, pp. 137-160, 1978.
75. Rauckman, E.J., Rosen, G.M. and Lefkowitz, R.J. Pharmacological activity of nitroxide analogues of dichlorisoproterenol and propranolol. J. Med. Chem. 19: 1254-1256, 1976.
76. Davis, J.N. and Lefkowitz, R.J. Beta-adrenergic receptor binding synaptic localization in rat brain. Brain Research 113: 214-220, 1976.
77. Caron, M.G. and Lefkowitz, R.J. Biological activity of agarose-immobilized catecholamines. Biochem. Biophys. Acta 444: 472-486, 1976.
78. Lefkowitz, R.J. Beta-adrenergic receptors: Recognition and regulation. New Engl. J. Med. 295: 323-328, 1976.
79. Williams, L.T., Mullikin, D. and Lefkowitz, R.J. Identification of alpha-adrenergic receptors in uterine smooth muscle membranes by [3H]dihydroergocryptine binding. J. Biol. Chem. 251: 6915-6923, 1976.
80. Lefkowitz, R.J. Regulation of beta-adrenergic receptors by beta-adrenergic agonists, in Hormone Receptors, Vol. II (B. O'Malley and L. Birnbaumer, eds.), Academic Press, New York.
81. Lefkowitz, R.J., Mukherjee, C., Caron, M.G., Mickey, J.V. and Tate, R. Biochemical mechanisms for regulation of beta-adrenergic receptors by beta-adrenergic agonists, in Proceedings of the Vth Interncrine Congressational Endo, 1976.
82. Mukherjee, C. and Lefkowitz, R.J. Regulation of beta-adrenergic receptors in isolated frog erythrocyte plasma membranes. Mol. Pharmacol. 13: 291-303, 1977.
83. Mukherjee, C. and Lefkowitz, R.J. Direct radioligand binding studies of beta-adrenergic receptors in intact frog erythrocytes. Life Sciences 19:1897, 1976
84. Lefkowitz, R.J. Desensitization of beta-adrenergic receptors by beta-adrenergic agonists, in Proceedings of the 10th CINP Congress (Collegium Internationale Neuro-Psychopharmacologicum), Pergamon Press, Ltd., 1976.
85. Lefkowitz, R.J. Smoking, catecholamines and the heart (signed editorial). New Engl. J. Med. 295: 615-616, 1976.
86. Lefkowitz, R.J. Radioligand binding studies of adrenergic receptors. Wenner-Gren Center International Symposium Series. in: Central Adrenaline Neurons (Ed. K. Ruxe, et al., Pergamon Press, Oxford & New York, pp. 291-301, 1976.
87. Limbird, L.E. and Lefkowitz, R.J. Resolution of beta-adrenergic receptors and adenylate cyclase by gel exclusion chromatography. J. Biol. Chem. 252: 799-802, 1977.
88. Williams, L.T. and Lefkowitz, R.J. Molecular pharmacology of alpha-adrenergic receptors: Use of [3H]dihydroergocryptine binding in the study of pharmacological receptor alterations. Mol. Pharmacol. 13: 304-313, 1977.
89. Randall, M.H., Altman, L.J. and Lefkowitz, R.J. Structure and biological activity of (-) [3H]dihydroalprenolol: A radioligand for studies of beta-adrenergic receptors. J. Med. Chem. 20:1090, 1977.
90. Williams, L.T., Gore, T. and Lefkowitz, R.J. Ectopic beta-adrenergic receptor binding sites: Possible molecular basis of aberrant catecholamine responsiveness of an adrenocortical tumor adenylate cyclase. J. Clin. Invest. 59: 319, 1977.
91. Lefkowitz, R.J. and Williams, L.T. Catecholamine binding to the beta-adrenergic receptor. Proc. Natl. Acad. Sci. USA 74: 515-519, 1977.
92. Davis, J.N., Strittmatter, W.J., Hoyler, E. and Lefkowitz, R.J. [3H]Dihydroergocryptine binding in rat brain. Brain Research 132: 327-336, 1977.
93. Williams, L.T., Pike, M., Snyderman, R. and Lefkowitz, R.J. Specific receptors for chemotactic peptides on human polymorphonuclear leukocytes. Proc. Natl. Acad. Sci. USA 74: 1204-1208, 1977.
94. Lefkowitz, R.J. Biochemical characteristics of alpha- and beta-adrenergic receptors and their relevance to the clinician. Cardiovasc. Med. 1977.
95. Lefkowitz, R.J. Identification and regulation of adrenergic receptors. Proceedings of the American Society of American Society of Neuropsychopharmacology Meeting, 1977.
96. Lefkowitz, R.J. Modulation of norepinephrine action at alpha and beta adrenergic receptors in hypertension. Report of the National Hypertension Task Force, 1977.
97. Williams, L.T., Lefkowitz, R.J., Hathaway, D.R., Watannabe, A.M. and Besch, H.R. Thyroid hormone regulation of beta-adrenergic receptor number. J. Biol. Chem. 252: 2787-2790, 1977.
98. Strittmatter, W.J., Davis, J.N. and Lefkowitz, R.J. Alpha-adrenergic receptors in rat parotid cells: I. Correlations of [3H]dihydroergocryptine binding and catecholamine stimulated potassium efflux. J. Biol Chem. 252: 5472-5477, 1977.
99. Strittmatter, W.J., Davis, J.N. and Lefkowitz, R.J. Alpha-adrenergic receptors in rat parotid cells: II. Desensitization of receptor binding sites and potassium release. J. Biol. Chem. 252: 5478-5482, 1977.
100. Lefkowitz, R.J. Identification and regulation of alpha- and beta-adrenergic receptors. Fed. Proc.,7: 123-129, 1978.
101. Lefkowitz, R.J. and Hamp, M. Comparison of agonist and antagonist radioligand binding to beta-adrenergic receptors. Nature 268: 453, 1977.
102. Williams, L.T. and Lefkowitz, R.J. Regulation of rabbit myometrial alpha-adrenergic receptors by estrogen and progesterone. J. Clin. Invest. 60: 815-818, 1977.
103. Lefkowitz, R.J., Mullikin D., Wood C., Gore, T. and Mukherjee, C. Regulation of prostaglandin receptors by prostaglandins and guanine nucleotides. J. Biol. Chem. 252: 5295-5303, 1977.
104. Williams, L.T. and Lefkowitz, R.J. Slowly reversible binding of a beta-adrenergic agonist to a nucleotide sensitive state of the beta-adrenergic receptor. J. Biol. Chem. 252: 7207-7213, 1977.
105. Lefkowitz, R.J. Molecular properties and regulation of alpha- and beta-adrenergic receptors. Proceedings of P & S Symposium on Neuronal Informations Transfer, pp. 59-71, Academic Press, New York, 1978.
106. Lefkowitz, R.J. Molecular mechanisms of activation and desensitization of adenylate cyclase coupled beta-adrenergic receptors. Advances in Cyclic Nucleotide Research, Vol. 9, (W.J. George and L.J. Ignarro, eds.), Raven Press, New York, 1978.
107. Pike, L.J. and Lefkowitz, R.J. Agonist-specific alterations in receptor binding affinity associated with solubilization of turkey erythrocyte membrane beta-adrenergic receptors. Mol. Pharmacol. 14: 370-375, 1978.
108. Glaubiger, G. and Lefkowitz, R.J. Elevated beta-adrenergic receptor number after chronic propranolol treatment. Biochem. Biophs. Res. Commun. 78: 720-725, 1977.
109. Lefkowitz, R.J. Molecular and regulatory properties of beta-adrenergic receptors and their clinical implications. Excerpta Medica Symposium on "Beta-adrenergic Blockade: A New Era in Cardiovascular Medicine," 1977.
110. Newman, K., Williams, L.T., Bishopric, N. and Lefkowitz, R.J. Identification of platelet alpha-adrenergic receptors by [3H]dihydroergocryptine binding. J. Clin. Invest. 61: 395-402, 1978.
111. Tsai, Bie Shung and Lefkowitz, R.J. [3H]Dihydroergocryptine binding to alpha-adrenergic receptors in canine aortic membranes. J. Pharm. Exp. Therap. 204: 606-614, 1978.
112. Lefkowitz, R.J. Recent advances in the study of drug receptors. Yearbook of Drug Therapy, 1978.
113. Caron, M.G., Beaubieu, M., Raymond, V., Drouin, J., Gagne, B., Lefkowitz, R.J. and Labrie, F. Dopaminergic receptors in the anterior pituitary gland: Identification by [3H]dihydroergocryptine binding. J. Biol. Chem. 253: 2244-2253, 1978.
114. Lefkowitz, R.J., Mullikin, D. and Williams, L.T. A desensitized state of the beta-adrenergic receptor not associated with high affinity agonist occupancy. Mol. Pharmacol. 14: 376-380, 1978.
115. Limbird, L. and Lefkowitz, R.J. Agonist-induced increase in apparent beta-adrenergic receptor size. Proc. Natl. Acad. Sci. USA 75: 228-232, 1978.
116. Williams, L.T., Mullikin, D. and Lefkowitz, R.J. Magnesium dependence of agonist binding to adenylate cyclase-coupled hormone receptors. J. Biol. Chem. 253: 2984-2989, 1978.
117. Tsai, B. Shung and Lefkowitz, R.J. Agonist specific effects of monovalent and divalent cations on adenylate cyclase coupled alpha-adrenergic receptors in rabbit platelets. Mol. Pharmacol. 14: 540, 1978.
118. Pike, L.J. and Lefkowitz, R.J. Multiple effects of N,N' dicyclohexyl carbodiimide on the beta-adrenergic receptor-adenylate cyclase system in frog erythrocytes. J. Cyclic Nucleotide Res. 4: 27-34, 1978.
119. Wessels, M.R., Mullikin, D. and Lefkowitz, R.J. Differences between agonist and antagonist binding following beta-adrenergic receptor desensitization. J. Biol. Chem. 253: 3371-3373, 1978.
120. Williams, R.S. and Lefkowitz, R.J. Alpha-adrenergic receptors in rat myocardium: Identification by binding of [3H]dihydroergocryptine. Circ. Res. 43: 721-727, 1978.
121. Glaubiger, G, Tsai, B.S., Lefkowitz, R.J., Johnson, E.M. and Weiss, B. Chronic guanethidine treatment increases cardiac beta-adrenergic receptors. Nature 273: 240-242, 1978.
122. Lefkowitz, R.J., Limbird, L.E., Williams, L.T. and Wessels, M. Beta-adrenergic receptors: Regulatory role of agonists. Keystone. J. of Supramol. Struct. 8: 501-510, 1978.
123. Clarke, W. and Lefkowitz, R.J. Hepatic alpha-adrenergic receptors: Identification and subcellular localization with [3H]dihydroergocryptine. J. Biol. Chem. 253: 5975-5979, 1978.
124. Caron, M., Williams, L.T. and Lefkowitz, R.J. Labelling of peripheral adrenoceptors. Proceedings of the Symposium on Adrenoceptors, Pergamon Press, 1978.
125. Williams, L.T. and Lefkowitz, R.J. Methodological approach to radioligand binding studies of adrenergic receptors. Proceedings of the Symposium on Adrenoceptors, Pergamon Press, 1978.
126. Lefkowitz, R.J., Williams, L.T., Pike, L.J. and Wessels, M. Receptor binding studies of beta-adrenergic receptors: New insights into activation and desensitization of adenylate cyclase. Proceedings of the 7th International Pharmacology Symposium, Pergamon Press, 1978.
127. Williams, L.T. and Lefkowitz, R.J. Pharmacology of the sympathetic nervous systems in "Beta-Blockers and Their Role in Hypertension." Med. Ed. Press, New Jersey, 1978.
128. Caron, M.G., Srinivasan, Y., Pitha, J. and Lefkowitz, R.J. The beta-adrenergic receptor of frog erythrocyte: Purifications by biospecific affinity chromatography. Proceedings of the IIIrd International Catecholamine Symposium, 547-549, 1978.
129. Wood, C.L., Arnett, C.D., Clarke, W.R., Tsai, B.S. and Lefkowitz, R.J. Subclassification of alpha-adrenergic receptors by direct binding studies. Biochem. Pharmacol. 28: 1277-1282, 1979.
130. Williams, R.S., Guthrow, E. and Lefkowitz, R.J. Beta-adrenergic receptors of human lymphocytes are unaltered by hyperthroidism. J. Clin. Endo. Metab. 48: 503-505, 1979.
131. Limbird, L.E., Hickey, A. and Lefkowitz, R.J. Unique uncoupling of the frog erythrocyte adenylate cyclase by manganese. J. Biol. Chem. 254: 2677-2683, 1979.
132. Caron, M.G., Srinivasan, Y., Pitha, J., Kiolek, K. and Lefkowitz, R.J. Affinity chromatography of the beta-adrenergic receptors. J. Biol. Chem. 254: 2923-2927, 1979.
133. Tsai, B.S. and Lefkowitz, R.J. Agonist-specific effects of guanine nucleotides on platelet alpha-adrenergic receptors. Mol. Pharmacol. 16: 61-68, 1979.
134. Williams, R.S. and Lefkowitz, R.J. Thyroid hormone regulation of alpha-adrenergic receptors: Studies in rat myocardium. J. Cardiovasc. Pharm. 1: 181-189, 1979.
135. Hancock, A., De Lean, A. and Lefkowitz, R.J. Quantitative resolution of beta-adrenergic receptor subtypes by selective ligand binding: Application of a computerized model fitting technique. Mol. Pharmacol. 16: 1-9, 1979.
136. Hoffman, B., Schocken, D., Wood, C., Tsai, B.S., De Lean, A. and Lefkowitz, R.J. Alpha-adrenergic receptor subtypes: Quantitative assessment by ligand binding. Life Sci. 24: 1739-1746, 1979.
137. Wood C., Caron, M.G. and Lefkowitz, R.J. Separation of alpha- and beta-adrenergic receptors by affinity chromatography. Biochem. Biophys. Res. Commun. 88: 1-8, 1979.
138. Wessels, M., Mullikin, D. and Lefkowitz, R.J. Selective alteration of high affinity agonist binding: A mechanism of beta-adrenergic receptor desensitization. Mol. Pharmacol. 16: 10-20, 1979.
139. Caron, M.G., Srinivasan, Y., Snyderman, R. and Lefkowitz, R.J. Antibodies raised against purified beta-adrenergic receptors specifically bind beta-adrenergic ligands. Proc. Natl. Acad. Sci. USA 76: 2263, 1979.
140. Limbird, L.E., De Lean, A., Pike, L.J., Hickey, A. and Lefkowitz, R.J. Differential effects of GTP on the coupling of beta-adrenergic receptors to adenylate cyclase from frog and turkey erythrocytes: Application of new methods for the analysis of receptor-effector coupling. Biochem. Biophys. Acta 586: 298-314, 1979.
141. Tsai, B.S. and Lefkowitz, R.J. Multiple effects of guanine nucleotides on human platelet adenylate cyclase. Biochem. Biophys. Acta 587: 28-41, 1979.
142. Pike, L.J. and Lefkowitz, R.J. Beta-adrenergic receptors determine affinity but not intrinsic activity of drugs for stimulation of adenylate cyclase. Nature 280: 502-504, 1979.
143. Limbird, L.E., Hickey, A.R. and Lefkowitz, R.J. The molecular size of adenylate cyclase in the absence and presence of nucleotide and hormone effectors. J. Cyclic Nucleotide Res. 5: 251, 1979.
144. Bishopric, N.H., Cohen, H. and Lefkowitz, R.J. Beta-adrenergic receptors in lymphocyte subpopulations. J. All. Clin. Immun. 65: 29-33, 1980.
145. Caron, M.G., Srinivasan, Y., and Lefkowitz, R.J. Affinity chromatography of the beta-adrenergic receptor and characterization of antibodies raised against purified receptor preparations. Proceedings of the 1st International Colloquium on Receptors, Raven Press , New York, 1979.
146. Lefkowitz, R.J. Direct radioligand binding studies of adrenergic receptors: Biochemical, physiological and clinical implications. Annal Intern. Med. 91: 450-558, 1979.
147. Caron, M.G., Limbird, L.E., and Lefkowitz, R.J. The beta-adrenergic receptor of the frog erythrocyte. Mol. Cell. Biochem. 28: 45-67, 1979.
148. Stadel, J. and Lefkowitz, R.J. Multiple reactive sulfhydryl groups modulate the function of adenylate cyclase coupled beta-adrenergic receptors. Mol. Pharmacol. 16: 709-718, 1979.
149. Hoffman, B.B. and Lefkowitz, R.J. Radioligand binding studies of adrenergic receptors: New insights into molecular and physiological regulation. Annu. Rev. Pharmacol. Toxicol. 20: 581-608, 1980.
150. Lefkowitz, R.J. and Hoffman, B.B. Adrenergic receptors. Adv. Cyclic Nucleotide Res., Vol. 12 (P. Hamet and H. Sands, eds.). Raven Press, New York, 1978.
151. Stadel, J., De Lean, A. and Lefkowitz, R.J. A high affinity agonist-beta-adrenergic receptor complex is an intermediate for catecholamine stimulation of adenylate cyclase in turkey and frog erythrocyte membranes. J. Biol. Chem. 255: 1436-1441, 1980.
152. Mukherjee, A., Wong, T.M., Buja, L.M., Lefkowitz, R.J. and Willerson, J.T. Beta-adrenergic and muscarinic cholinergic receptors in canine myocardium: Effects of ischemia. J. Clin. Invest. 64: 1423-1428, 1979.


153. Voeikov, V.L. and Lefkowitz, R.J. Effects of local anesthetic on guanyl nucleotide modulation of the catecholamine sensitive adenylate cyclase systems and on beta-adrenergic receptors. Biochem. Biophys. Acta 629: 266, 1980.
154. Hoffman, B.B. and Lefkowitz, R.J. An assay for alpha-adrenergic receptor subtypes using [3H]-dihydroergocryptine. Biochem. Pharmacol. 29: 452-454, 1980.
155. Kent, R.S., De Lean, A. and Lefkowitz, R.J. Quantitative analysis of beta-adrenergic receptor interactions: Resolution of high and low affinity states of the receptor by computer modelling of ligand binding data. Mol. Pharmacol. 17: 14-23, 1980.
156. De Lean, A. and Lefkowitz, R.J. A comment on [3H]dihydroergocryptine binding in uterine membranes. Nature 283: 109-110, 1980.
157. Davies, A. and Lefkowitz, R.J. Regulation of adrenergic receptors in Recent Advances in Clinical Pharmacology, (D. Shand, ed.). Churchill Livingstone Press, 1979.
158. McConnaughey, M.M., Jones, L.R., Watanabe, A.M., Besch, H.R., Jr., Williams, L.T. and Lefkowitz, R.J. Thyroxine and propylthiouracil effects on alpha- and beta-adrenergic receptor number, ATPase activities and sialic acid content of rat cardiac membrane vesicles. J. Cardiovasc. Pharm. 1:609-624, 1979.
159. Hoffman, B.B., Mullikin-Kilpatrick, D. and Lefkowitz, R.J. Desensitization of beta-adrenergic stimulated adenylate cyclase in turkey erythrocytes. J. Cyclic Nucleotide Res. 5: 355-366, 1979.
160. Limbird, L.E., Gill, M. and Lefkowitz, R.J. Agonist promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein. Proc. Natl. Acad. Sci. USA 77: 775-779, 1980.
161. Limbird, L.E., Gill, M., Stadel, J.M., Hickey, A.R. and Lefkowitz, R.J. Loss of beta-adrenergic receptor-guanine nucleotide regulatory protein interactions accompanies decline in catecholamine responsiveness of adenylate cyclase in maturing rat erythrocytes. J. Biol. Chem. 255: 1854-1861, 1980.
162. Lefkowitz, R.J., Wessels, M. and Stadel, J. Hormones, receptors and cyclic AMP: Their role in target cell refractoriness in Current Topics in Cellular Regulation, (B. Horecker and E. Stadtman, eds.), 17: 205-230, 1980
163. Lefkowitz, R.J. Alpha- and beta-adrenergic receptors in Biochemical Regulation of Blood Pressure, (R. Soffer, ed.). Wiley and Sons, New York, pp. 283-299, 1982.
164. Hoffman, B.B. and Lefkowitz, R.J. [3H]WB4101: Caution about its role as an alpha-adrenergic subtype selective radioligand. Biochem. Pharmacol. 29: 1537-1541, 1980.
165. Lefkowitz, R.J. Technical points for using (-)[3H]dihydroalprenolol in the study of beta-adrenergic receptors in Receptor Site Analysis, Technical Bulletin of New England Nuclear Co., 1979.
166. Hoffman, B.B. and Lefkowitz, R.J. Radioligand binding studies of peripheral alpha-adrenergic receptor subtypes in Proceedings of the American College of Neuropsychopharmacology Meeting, (E. Usdin, ed.), 1979.
167. Schocken, D., Caron, M.G. and Lefkowitz, R.J. The human placenta--A rich source of beta-adrenergic receptors: Characterization of the receptors in particulate and solubilized preparations. J. Clin. Endo. Metab. 50: 1082-1088, 1980.
168. Pitha, J., Zjawiony, J., Lefkowitz, R.J. and Caron, M.G. Macromolecular beta-adrenergic Antagonist discriminating between receptor and antibody. Proc. Natl. Acad. Sci. USA 77: 2219-2223, 1980.
169. Williams, R.S. and Lefkowitz, R.J. The effects of thyroid hormones on adrenergic receptors in Molecular Basis of Thyroid Hormone Action, (A. Samuels and J. Oppenheimer, eds.). Academic Press, New York, 1980.
170. Stadel, J. and Lefkowitz, R.J. Molecular mechanisms of desensitization of the beta-adrenergic receptor coupled adenylate cyclase. Proc. of the Western Pharmacology Society 23: 469-475, 1980.
171. Hoffman, B.B. and Lefkowitz, R.J. Heterogeneity of radioligand binding to alpha-adrenergic receptors: Analysis of guanine nucleotide regulation in relation to receptor subtypes. J. Biol. Chem. 255: 4645-4652, 1980.
172. Lefkowitz, R.J. Recent developments in adrenergic receptor research. Annual Reports in Medicinal Chemistry 15: 217, 1980.
173. Pike, L.J. and Lefkowitz, R.J. Activation and desensitization of beta-adrenergic receptor coupled GTPase and adenylate cyclase of frog and turkey erythrocyte membranes. J. Biol. Chem. 255: 6860-6867, 1980.
174. Lefkowitz, R.J. Modifications of adenylate cyclase activity by alpha-and beta-adrenergic receptors: Insights from radioligand binding studies. Proceedings of the Conference on Neurotransmitter Receptors, (E. Usdin, ed.). Pergamon Press, New York, 1980.
175. De Lean, A., Stadel, J.M. and Lefkowitz, R.J. A ternary complex model explains the agonist-specific binding properties of the adenylate-cyclase coupled beta-adrenergic receptor. J. Biol. Chem. 255: 7108-7117, 1980.
176. Davies, A.O. and Lefkowitz, R.J. Corticosteroid-induced differential regulation of beta-adrenergic receptors on lymphocytes and polymorphonuclear leukocytes. J. Clin. Endo. Metab. 51: 599, 1980.
177. Hoffman, B.B., Michel, T., Mullikin-Kilpatrick, D., Lefkowitz, R.J., Tolbert, M.E., Gilman, H. and Fain, J. Agonist versus antagonist binding to alpha-adrenergic receptors. Proc. Natl. Acad. Sci. USA 77: 4569-4573, 1980.
178. Briggs, M.M. and Lefkowitz, R.J. Parallel modulation of catecholamine activation of adenylate cyclase and formation of high affinity agonist receptor complex in turkey erythrocyte membranes by temperature and cis-vaccenic acid. Biochemistry 19: 4461-4465, 1980.
179. Pike, L.J. and Lefkowitz, R.J. Use of cell fusion techniques to probe the mechanism of catecholamine-induced desensitization of adenylate cyclase in frog erythrocytes. Biochem. Biophys. Acta. 632: 354-365, 1980.
180. Lefkowitz, R.J. and Hoffman, B.B. New directions in adrenergic receptor research. Part I - Trends in Pharmacological Sciences, 1: 314-317, 1980.
181. Lefkowitz, R.J. and Hoffman, B.B. New directions in adrenergic receptor research. Part II - Trends in Pharmacological Sciences, 1: 369-372, 1980.
182. Stadel, J., De Lean, A. and Lefkowitz, R.J. Molecular mechanisms of coupling in hormone-receptor-adenylate cyclase systems. Advances in Enzymology 53: 1-43, 1982.
183. Hoffman, B.B. and Lefkowitz, R.J. Alpha-adrenergic receptor subtypes. N. Engl. J. Med. 302: 1390-1396, 1980.
184. Lefkowitz, R.J. Pharmacological principles related to the autonomic nervous system in Cecil Textbook of Medicine, 16th Edition, (James B. Wyngaarden and Lloyd H. Smith, Jr., eds.), 1981.
185. Lefkowitz, R.J. Mechanisms for regulation of beta-adrenergic receptor function in desensitization. Proceedings of the World Conference on Clinical Pharmacology and Therapeutics. Macmillan Journals, Ltd., pp. 145-153, 1980.
186. Garcia-Sainz, J.A., Hoffman, B.B., Li, S.Y., Lefkowitz, R.J. and Fain, J. Role of alpha1-adrenoceptors in the turnover of phosphatidylinositol and of alpha2-adrenoceptors in the regulation of cyclic AMP accumulation in hamster adipocytes. Life Sci. 27: 953-962, 1980.
187. Lefkowitz, R.J., De Lean, A., Hoffman, B.B., Stadel, J.M., Kent, R., Michel, T. and Limbird, L.E. Molecular pharmacology of adenylate cyclase coupled alpha- and beta-adrenergic receptors. Advances in Cyclic Nucleotide Research 14: 145-161, 1981.
188. Michel, T., Hoffman, B.B. and Lefkowitz, R.J. Differential regulation of the alpha2-adrenergic receptor by Na+ and guanine nucleotides. Nature 288: 709-711, 1980.
189. Pike, L.J. and Lefkowitz, R.J. Correlation of beta-adrenergic receptor stimulated [3H]GDP release and adenylate cyclase activation: Differences between frog and turkey erythrocyte membranes. J. Biol. Chem. 256: 2207-2212, 1981.
190. Pitha, J., Zjawiony, J.Z., Nasrin, N., Lefkowitz, R.J. and Caron, M.G. Potent beta-adrenergic antagonist possessing chemically reactive group. Life Sci. 27: 1791-1798, 1980.
191. Lefkowitz, R.J. The sympathetic nervous system, catecholamine receptors and hypertension. Frontiers in Hypertension Research (John H. Laragh, Fritz R. Buhler and Donald W. Seldin, eds.), Springer Verlag, pp. 312-315, 1981.
192. Caron, M.G., Shorr, R.G.L. and Lefkowitz, R.J. Isolation and characterization of the beta-adrenergic receptor of frog erythrocytes and development of potential affinity ligands. Adv. Cyclic Nucleotide Res. 14: 127-134, 1981.
193. Hoffman, B.B., Dukes, D. and Lefkowitz, R.J. Alpha-adrenergic receptor subtypes in liver membranes: Delineation with subtype selective radioligands. Life Sci. 28: 265-272, 1981.
194. Burns, T.W., Langley, P.E., Terry, B.E., Bylund, D.B., Hoffman, B.B., Tharp, M.D., Lefkowitz, R.J., Garcia-Sainz, J.A. and Fain, J.N. Pharmacological characterization of adrenergic receptors in human adipocytes. J. Clin. Invest. 67: 467-475, 1981.
195. Burgisser, E., Lefkowitz, R.J. and De Lean, A. Anomalous equilibrium binding properties of high affinity racemic radioligands. Mol. Pharmacol. 19: 205-216, 1981.
196. Davies, A., De Lean, A. and Lefkowitz, R.J. Myocardial beta-adrenergic receptors from adrenalectomized rats: Impaired formation of high affinity agonist receptor complexes. Endocrinology 108: 720-722, 1981.
197. Tharp, M., Hoffman, B.B. and Lefkowitz, R.J. Alpha-adrenergic receptors in human adipocyte membranes: Identification by [3H]yohimbine binding. J. Clin. Endo. Metab. 52: 709-714, 1981.
198. Williams, R.S., Dukes, D.F. and Lefkowitz, R.J. Subtype specificity of alpha-adrenergic receptors in rat heart. J. Cardiovasc. Pharmacol. 3: 522-531, 1981.
199. Burgisser, E., De Lean, A. and Lefkowitz, R.J. Alternative explanation for the apparent "two step" binding kinetics of high affinity racemic radioligands. Mol. Pharmacol. 19: 509-512, 1981.
200. Davies, A.O. and Lefkowitz, R.J. Regulation of adrenergic receptors in Receptor Regulation, (R.J. Lefkowitz, ed.). Churchill Livingstone, London, Series B, Vol. 13, pp. 83-121, 1981.
201. Lefkowitz, R.J. Biochemical mechanisms of hormone receptor-effector coupling. Minisymposium presented at the 72nd Annual Meeting of the American Society of Biological Chemists, pp. 48-49, 1981.
202. Michel, T., Hoffman, B. and Lefkowitz, R.J. Regulation of adenylate cyclase by adrenergic receptors in Biochemical Actions of Hormones, (G. Litwack, ed.). Academic Press, New York, pp. 43-68, 1982.
203. Lavin, T.N., Hoffman, B.B. and Lefkowitz, R.J. Determination of subtype selectivity of alpha-adrenergic antagonists: Comparison of selective and non-selective radioligands. Mol. Pharmacol. 20: 28-34, 1981.
204. Shorr, R., Lefkowitz, R.J. and Caron, M. Purification of the beta-adrenergic receptor: Identification of the hormone binding subunit. J. Biol. Chem. 256: 5820-5826, 1981.
205. Stiles, G.L. and Lefkowitz, R.J. Thyroid hormone modulation of agonist-beta-adrenergic receptor interactions in the rat heart. Life Sci. 28: 2529-2536, 1981.
206. Hoffman, B.B. and Lefkowitz, R.J. Adrenergic receptors in the heart. Annu. Rev. Physiol. 44: 475-484, 1982.
207. Hoffman, B.B., Yim, S., Tsai, B.S. and Lefkowitz, R.J. Preferential uncoupling by manganese of alpha adrenergic receptor mediated inhibition of adenylate cyclase in human platelets. Biochem. Biophys. Res. Commun. 100: 724, 1981.
208. Davies, A.O. and Lefkowitz, R.J. Agonist promoted high affinity state of the beta-adrenergic receptors in human neutrophils: Modulation by corticosteroids. J. Clin. Endo. Metab. 53: 703-708, 1981.
209. Michel, T., Hoffman, B.B., Lefkowitz, R.J. and Caron, M.G. Different sedimentation properties of agonist and antagonist-labelled alpha2 adrenergic receptors. Biochem. Biophys. Res. Commun., 100: 1131-1136, 1981.
210. Stadel, J., Mullikin, D., Dukes, D. and Lefkowitz, R.J. Catecholamine-induced desensitization in turkey erythrocytes: cAMP mediated impairment of high affinity agonist binding without alteration in receptor number. J. Cyclic Nucleotide Res. 7: 37-47, 1981.
211. Stiles, G.L. and Lefkowitz, R.J. Identification and characterization of beta-adrenergic receptors in myocardium under normal and pathologic conditions in Catecholamines and the Heart, (W. Delius, E. Gerlach, H. Grobecker and W. Kubler, eds.). Springer-Verlag, 1981, pp. 61-71.
212. Hoffman, B.B. and Lefkowitz, R.J. Agonist interactions with alpha adrenergic receptors. J. Cardiovasc. Pharmacol. 4: 514-518, 1982.
213. Stadel, J.M., Shorr, R.G.L., Limbird, L.E. and Lefkowitz, R.J. Evidence that a beta-adrenergic receptor associated guanine nucleotide regulatory protein conveys GTP-cS dependent adenylate cyclase activity. J. Bio. Chem. 256: 8718-8723, 1981.
214. Hoffman, B.B., Lavin, T.N., Lefkowitz, R.J. and Ruffolo, R.R., Jr. Alpha-adrenergic receptor subtypes in rabbit uterus: Mediation of myometrial contraction and regulation by estrogens. J. Pharmacol. Exp. Ther. 219: 290-295, 1981.
215. Stiles, G.L., Stadel, J.M., De Lean, A. and Lefkowitz, R.J. Hypothyroidism modulates beta-adrenergic receptor-adenylate cyclase interactions in rat reticulocytes. J. Clin. Invest. 68: 1450-1455, 1981.
216. De Lean, A., Hancock, A. and Lefkowitz, R.J. Validation and statistical analysis of a computer modelling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes. Mol. Pharmacol. 21: 5-16, 1982.
217. Lavin, T., Heald, S., Jeffs, P., Shorr, R., Lefkowitz, R.J. and Caron, M.G. Photoaffinity labelling of the beta-adrenergic receptor. J. Biol. Chem. 256: 11944-11950, 1981.
218. Pitha, J., Zjawiony, J., Lefkowitz, R.J. and Caron, M.G. Polymeric drugs by direct copolymerization: Polymer of beta-adrenergic antagonist alprenolol and its binding to receptors and antibodies. Makromol. Chem. 182: 1945-1950, 1981.
219. Garcia-Sainz, J.A., Litosch, I., Hoffman, B.B., Lefkowitz, R.J. and Fain, J.N. Effect of thyroid status on alpha- and beta-catecholamine responsiveness of hamster adipocytes. Biochem. Biophys. Acta 678: 334-341, 1981.
220. Franki, J.E., Jakoi, L., Davies, A.O., Lefkowitz, R.J., Snyderman, R. and Lazarus, G.S. Polymorphonuclear leukocyte function in psoriasis: Chemotaxis, chemokinesis, beta-adrenergic receptors and proteolytic enzymes of polymorphonuclear leukocytes in the peripheral blood from psoriatic patients. J. Invest. Dermatol. 81: 254-257, 1983.
221. Stiles, G. and Lefkowitz, R.J. Characterization of alpha- and beta-adrenergic receptors by biochemical methods in Alpha- and Beta-Adrenoceptors and the Cardiovascular System, (R.P. Ahlquist and W. Kobinger, eds.). Excerpta Medica, 1981.
222. Hoffman, B.B., Michel, T. and Lefkowitz, R.J. Interactions of agonists with platelet alpha2 adrenergic receptors. Endocrinology 110: 926-932, 1982.
223. Burgisser, E., De Lean, A. and Lefkowitz, R.J. Reciprocal modulation of agonist and antagonist binding to muscarinic cholinergic receptors by guanine nucleotides. Proc. Natl. Acad. Sci. USA 79: 1732-1736, 1982.
224. Briggs, M. and Lefkowitz, R.J. The beta-adrenergic receptor and adenylate cyclase: Model system for the study of transmembrane signalling in Cellular Regulation of Secretion and Release, (M. Conn, ed.). Academic Press, New York, pp. 23-49, 1982.
225. Lefkowitz, R.J. Receptor heterogeneity: Subtypes vs. ligand-induced alterations in Membrane Transport and Neuroreceptors (D. Oxender, A. Blume, I. Diamond and C.F. Fox, eds.). Alan R. Liss, Inc., New York, pp. 431-432, 1981.
226. Lefkowitz, R.J., Caron, M.G., Michel, T. and Stadel, J.M. Mechanisms of hormone receptor-effector coupling: The beta-adrenergic receptor and adenylate cyclase. Fed. Proc. 41: 2664-2670, 1982.
227. Caron, M.G., Lavin, T., Shorr, R.G. and Lefkowitz, R.J. Purification and photoaffinity labelling of the beta-adrenergic receptor of frog erythrocytes. Metabolism 31: 658-663, 1982.
228. Stadel, J. and Lefkowitz, R.J. The beta-adrenergic receptor: Ligand binding studies illuminate the mechanism of receptor-adenylate cyclase coupling in Current Topics in Membranes and Transport, (R. Martin and A. Kleinzeller, eds.). Academic Press, New York, Vol. 18, pp. 45-66, 1983.
229. Lefkowitz, R.J. Clinical physiology of adrenergic receptor regulation. Amer. J. Physiol. 243: E43-E47, 1982.
230. Shorr, R.G.L., Heald, S.L., Jeffs, P.W., Lavin, T.N., Strohsacker, M.W., Lefkowitz, R.J. and Caron, M.G. The beta-adrenergic receptor: Rapid purification and covalent labelling by photoaffinity crosslinking. Proc. Natl. Acad. Sci. USA 79: 2778-2782, 1982.
231. Stiles, G.L. and Lefkowitz, R.J. Hormone-sensitive adenylate cyclase: Delineation of a trypsin-sensitive site in the pathway of receptor-mediated inhibition. J. Biol. Chem. 257: 6287-6291, 1982.
232. Stadel, J. and Lefkowitz, R.J. Differential effects of cholera toxin on guanine nucleotide regulation of beta-adrenergic agonist high affinity binding and adenylate cyclase activation in frog erythrocyte membranes. J. Cyclic Nucleotide Res. 7: 363-374, 1981.
233. Wikberg, J. and Lefkowitz, R.J. Adrenergic receptors in the heart: Pre- and postsynaptic mechanisms in nervous control of cardiovascular function. Oxford University Press, 1982.
234. Stiles, G.L. and Lefkowitz, R.J. A reconstitution assay for the guanine nucleotide regulatory protein of the adenylate cyclase system using the turkey erythrocyte membrane as the acceptor. Arch. Biochem. Biophys.. 217: 368-375, 1982.
235. Koo, C., Lefkowitz, R.J. and Snyderman, R. The oligopeptide chemotactic factor receptor on human polymorphonuclear leukocyte membranes exists in two affinity states. Biochem. Biophys. Res. Commun. 106: 442-449, 1982.
236. Stiles, G.L. and Lefkowitz, R.J. Human platelet adenylate cyclase: Delineation of distinct stimulatory and inhibitory guanine nucleotide regulatory pathways. Transactions of the Association of American Physicians Volume XCV, pp. 244-252, 1982.
237. Stiles, G.L., Hoffman, B.B., Hubbard, M., Caron, M.G. and Lefkowitz, R.J. Guanine nucleotides and alpha1 adrenergic receptors in the heart. Biochem. Pharmacol. 32: 69-71, 1983.
238. Stadel, J.M., Nambi, P., Lavin, T.N., Heald, S.L., Caron, M.G. and Lefkowitz, R.J. Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase: Structural alterations in the beta-adrenergic receptor revealed by photoaffinity labelling. J. Biol. Chem. 257: 9242-9245, 1982.
239. Shorr, R.G.L., Strohsacker, M.W., Lavin, T.N., Lefkowitz, R.J. and Caron, M.G. The beta1-adrenergic receptor of the turkey erythrocyte: Molecular heterogeneity revealed by purification and photoaffinity labelling. J. Biol. Chem. 257: 12341-12350, 1982.
240. Lavin, T.N., Nambi, P., Heald, S.L., Jeffs, P.W., Lefkowitz, R.J. and Caron, M.G. [125I]Para-azidobenzylcarazolol, a photoaffinity label for the beta-adrenergic receptor: Characterization of the ligand and photoaffinity labelling of beta1 and beta2 adrenergic receptors. J. Biol. Chem. 257: 12332-12340, 1982.
241. Heinsimer, J.A. and Lefkowitz, R.J. Adrenergic receptors: Biochemistry, Regulation, molecular mechanisms and clinical implications. J. Lab. Clin. Med. 100: 641-658, 1983.
242. Vale, R.D., De Lean, A., Lefkowitz, R.J. and Stadel, J.M. Regulation of insulin receptors in frog erythrocytes by insulin and concanavalin A: Evidence for discrete classes of insulin binding sites. Mol. Pharmacol. 22: 619-626, 1982.
243. Michel, T. and Lefkowitz, R.J. Hormonal inhibition of adenylate cyclase: Alpha2 adrenergic receptors promote release of [3H]Gpp(NH)p from platelet membranes. J. Biol. Chem. 257: 13557-13563, 1982.
244. Wikberg, J. and Lefkowitz, R.J. Alpha2 adrenergic receptors are located prejunctionally in the Auerbach's plexus of the guinea pig small intestine: Direct demonstration by radioligand binding. Life Sci. 31: 2899-2905, 1982.
245. Lefkowitz, R.J., Stadel, J.M. and Caron, M.G. Adenylate cyclase-coupled beta-adrenergic receptors: Structure and mechanisms of activation and desensitization. Annu. Rev. Biochem. 52: 159-186, 1983.
246. Regan, J., Barden, N., Lefkowitz, R.J., Caron, M.G., DeMarinis, R.M., Krog, A.J., Holden, K.G., Matthews, W.D. and Hieble, J.P. Affinity chromatography of human platelet alpha2-adrenergic receptors. Proc. Natl. Acad. Sci. USA 79: 7223-7227, 1982.
247. Stadel, J.M., Strulovici, B., Nambi, P., Lavin, T.N., Briggs, M.M., Caron, M.G. and Lefkowitz, R.J. Desensitization of the beta adrenergic receptor of frog erythrocytes: Recovery and characterization of the down regulated receptors in sequestered vesicles. J. Biol. Chem. 258: 3032-3038, 1983.
248. Benovic, J.L., Stiles, G.L., Lefkowitz, R.J. and Caron, M.G. Photoaffinity labelling of mammalian beta-adrenergic receptors: Metal-dependent proteolysis explains apparent heterogeneity. Biochem. Biophys. Res. Commun. 110: 504-511, 1983.
249. Heald, S.L., Jeffs, P.W., Lavin, T.N, Nambi, P., Lefkowitz, R.J. and Caron, M.G. Synthesis of [125I]-labelled (~)-15-[4'-azidobenzyl]-carazolol: A potent beta-adrenergic photoaffinity probe. J. Med. Chem. 26: 832-838, 1983.
250. Davies, A.O. and Lefkowitz, R.J. In vitro desensitization of beta-adrenergic receptors in human neutrophils: Attenuation by corticosteroids. J. Clin. Invest. 71: 565-571, 1983.
251. Strader, C.D., Pickel, V.M., Joh, T.H., Strohsacker, M.W., Shorr, R.G.L., Lefkowitz, R.J. and Caron, M.G. Antibodies to the beta-adrenergic receptor: Attenuation of catecholamine-sensitive adenylate cyclase and demonstration of postsynaptic receptor localization in brain. Proc. Natl. Acad. Sci. USA 80: 1840-1844, 1983.
252. Lefkowitz, R.J. Adrenergic receptors: Regulation at the biochemical, physiological and clinical levels. Transactions of the American Clinical and Climatological Association 94: 75-90, 1983.
253. Stadel, J.M., Nambi, P., Shorr, R.G.L., Sawyer, D.F., Caron, M.G. and Lefkowitz, R.J. Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta adrenergic receptor. Proc. Natl. Acad. Sci. USA 80: 3173-3177, 1983.
254. Strulovici, B., Stadel, J.M. and Lefkowitz, R.J. Functional integrity of desensitized beta-adrenergic receptors: Internalized receptors reconstitute catecholamine stimulated adenylate cyclase activity. J. Biol. Chem. 258: 6410-6414, 1983.
255. Briggs, M.M., Stadel, J.M., Iyengar, R. and Lefkowitz, R.J. Functional modification of the guanine nucleotide regulatory protein after desensitization of turkey erythrocytes by catecholamines. Arch. Biochem. Biophys. 224: 142-151, 1983.
256. Kao, K.-J., Tsai, B.-S., McKee, P.A., Lefkowitz, R.J. and Pizzo, S.V. Inhibitory effect of ristocetin and factor VIII/Von Willebrand factor protein on human platelet adenylate cyclase activity. Thromb. Res., 1983.
257. Burgisser, E. and Lefkowitz, R.J. b-adrenergic receptors. Brain Receptor Methodologies Part A - General Methods and Concepts. Amines and Acetylcholine (P.J. Marangos, I. Campbell and R.M. Cohen, eds.), Academic Press, Orlando, Florida, pp. 229-253, 1984.
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259. Koo, C., Lefkowitz, R.J. and Snyderman, R. Guanine nucleotides modulate the binding affinity of the oligopeptide chemoattractant receptor on human polymorphonuclear leukocytes. J. Clin. Invest., 72:748-753, 1983.
260. Davies, A.O. and Lefkowitz, R.J. Regulation of beta-adrenergic receptors by steroid hormones. Annu. Rev. Physiol. 46: 119-130, 1984.
261. Wikberg, J.E.S., Lefkowitz, R.J. and Caron, M.G. Solubilization of rat liver alpha1 adrenergic receptors: Agonist specific alteration in receptor binding affinity. Biochem. Pharmacol. 32: 3171-3178, 1983.
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272. Stiles, G.L., Caron, M.G. and Lefkowitz, R.J. The b-adrenergic receptor: Structure, function and regulation in Mechanisms of Drug Action. Academic Press, New York, pp. 37-48, 1983.
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275. Caron, M.G., Leeb-Lundberg, L.M.F., Strader, C.D., Dickinson, K.E.J., Pickel, V.M., Joh, T. and Lefkowitz, R.J. Molecular biology of adrenergic receptors in the rat and frog central nervous system. Hypertension 6: II-22 - II-27, 1984.
276. Leeb-Lundberg, L.M.F., Dickinson, K.E.J., Heald, S.L., Wikberg, J.E.S., DeBernardis, J.F., Winn, M., Arendsen, D.L., Lefkowitz, R.J. and Caron, M.G. Covalent labeling of the cerebral cortex a1-adrenergic receptor with a new high affinity radioiodinated photoaffinity probe. Biochem. Biophys. Res. Commun. 115: 946-951, 1983.
277. Cerione, R.A., Strulovici, B., Benovic, J.L., Lefkowitz, R.J. and Caron, M.G. The pure b-drenergic receptor: A single polypeptide confers catecholamine responsiveness to an adenylate cyclase system. Nature 306: 562-566, 1983.
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292. Stiles, G.L. and Lefkowitz, R.J. Thyroid hormones and the b-adrenergic receptor-adenylate cyclase system. Thyroid Today VII: 1-6, 1984.
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297. Nambi, P., Sibley, D.R., Caron, M.G. and Lefkowitz, R.J. Photoaffinity labeling of b-adrenergic receptors in mammalian tissues. Biochem. Pharmacol. 33: 3813-3822, 1984.
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331. Nambi, P., Sibley, D.R. and Lefkowitz, R.J. Sensitization of frog erythrocyte adenylate cyclase system by tumor promoting phorbol diesters. Can. J. Physiol. Pharmacol. 63: 983-986, 1985.
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405. Collins, S., Caron, M.G. and Lefkowitz, R.J. b-Adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids. J. Biol. Chem. 263:9067-9070, 1988.
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412. Frielle, T., Daniel, K.W., Caron, M.G. and Lefkowitz, R.J. Structural basis of b-adrenergic receptor subtype specificity studied with chimeric b1/b2-adrenergic receptors. Proc. Natl. Acad. Sci. USA, 85:9494-9498, 1988.
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415. Benovic, J.L., Stone, W.C., Caron, M.G. and Lefkowitz, R.J. Inhibition of the b-adrenergic receptor kinase by polyanions. J. Biol. Chem. 264:6707-6710, 1989.
416. Matsui, H., Lefkowitz, R.J., Caron, M.G. and Regan, J.W. Localization of the fourth membrane spanning domain as a ligand binding site in the human platelet a2-adrenergic receptor. Biochemistry 28:4125-4130, 1989.
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419. Palacios, J.M., O'Dowd, B.F., Cotecchia, S., Hnatowich, M.G. Caron and R.J. Lefkowitz. Adrenergic receptor homologies in vertebrate and invertebrate species examined by DNA hybridization. Life Sciences 44:2057-2065, 1989.
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426. Raymond, J.R., Fargin, A., Lohse, M.J., Regan, J.W., Senogles, S.E., Lefkowitz, R.J. and M.G. Caron. Identification of the ligand binding subunit of the human 5-HT1A receptor with [125I]-N3-NAPS, a high affinity radioiodinated photoaffinity probe. Mol. Pharmacol. 36:15-21, 1989.
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484. Oakey, R.J., Caron, M.G., Lefkowitz, R.J., and Seldin, M.F. Genomic organization of adrenergic and serotonin receptors in the mouse: Linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution. Genomics 10:338-344, 1991.
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542. Boekhoff, I., Inglese, J., Schleicher, S., Koch, W.J., Lefkowitz, R.J. and Breer, H. Olfactory desensitization requires membrane targeting of receptor kinase mediated by bg-subunits of heterotrimeric G. proteins. J. Biol. Chem., 269:37-40, 1994.
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544. Price, D.T., Lefkowitz, R.J., Caron, M.G., Berkowitz, D. and Schwinn, D.A. Localization of mRNA for three distinct a1-adrenergic receptor subtypes in human tissues: Implications for human a-adrenergic physiology. Mol. Pharmacol., 45:171-175, 1994.
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546. Koch, W.J., Hawes, B.E., Inglese, J., Luttrell, L.M. and Lefkowitz, R.J. Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates Gbg-mediated signaling. J. Biol. Chem., 269:6193-6197, 1994.
547. Samama, P., Pei, G., Costa, T., Cotecchia, S. and Lefkowitz, R.J. Negative antagonists promote an inactive conformation of the b2-adrenergic receptor. Mol. Pharmacol., 45:390-394, 1994.
548. Premont, R.T., Koch, W.J., Inglese and Lefkowitz, R.J. Identification, purification and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. J. Biol. Chem., 269:6832-6841, 1994.
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550. Pei, G., Samama, P., Lohse, M., Wang, M., Codina, J. and Lefkowitz, R.J. A constitutively active mutant b2-adrenergic receptor is constitutively desensitized and phosphorylated. Proc. Natl. Acad. Sci., USA., 91:2699-2702, 1994.
551. Pei, G., Tiberi, M., Caron, M.G. and Lefkowitz, R.J. Novel approach to the study of G protein-couple receptor kinases: An in vitro purified membrane assay reveals differential receptor specificity and regulation by Gbg. Proc. Natl. Acad. Sci., USA, 91:3633-3636, 1994.
552. Inglese, J., Luttrell, L.M., Iniguez-Lluhi, J., Touhara, K., Koch, W.J. and Lefkowitz, R.J. Functionally active targeting domain of the b-adrenergic receptor kinase: An inhibitor of the Gbg-mediated stimulation of type II adenylyl cyclase. Proc. Natl. Acad. Sci,, USA, 91:3637-3641, 1994.
553. Touhara, K., Inglese, J., Pitcher, J., Shaw, G. and Lefkowitz, R.J. Binding of G protein bg-subunits to pleckstrin homology domains. J. Biol. Chem., 269:10217-10220, 1994.
554. Kurose, H. and Lefkowitz, R.J. Differential desensitization and phosphorylation of three cloned and transfected a2-adrenergic receptor subtypes. J. Biol. Chem., 269:10093-10099, 1994.
555. Milano, C.A., Allen, L.F., Rockman, H.A., Dolber, P.C., McMinn, T.R., Chien, K.R., Johnson, T.D., Bond, R.A. and Lefkowitz, R.J. Markedly enhanced myocardial function in transgenic mice with cardiac overexpression of the human beta2-adrenergic receptor. Science, 264:582-586, 1994.
556. Hawes, B.E., Luttrell, L.M., Exum S.T. and Lefkowitz, R.J. Inhibition of G protein-coupled receptor signalling by expression of cytoplasmic domains of the receptor. J. Biol. Chem., 269:15776-15787, 1994.
557. Milano, C.A., Allen, L.F., Dolber, P.C. and Lefkowitz, R.J. Overexpression of a constitutively active a1-adrenergic receptor in transgenic mice induces cardia hypertrophy. Surgical Forum, American college of Surgeons., 45:304-306, 1994.
558. Reuveny, E., Slesinger, P.A., Inglese, J., Morales, J.M., Iniguez-Lluhi, J.A. Lefkowitz, R.J., Bourne, H.R., Jan, Y.N. and Jan, L.Y. Activation of the cloned muscarinic potassium channel by G protein bg subunits. Nature, 370:143-146, 1994.
559. Milano, C.A., Dolber, P.C., Rockman, H.A., Bond, R.A., Venable, M.E., Allen, L.F. and Lefkowitz, R.J. Myocardial expression of a constitutively active alpha 1B-adreneric receptor in transgenic mice induces cardiac hypertrophy. Proc. Natl. Acad. Sci., USA, , 91:10109-10133, 1994.
560. Kwatra, M.M., Lefkowitz, R.J. and Caron, M.G. Partially purified and reconstituted G protein-coupled receptors as substrates of specific receptor kinases. In: Methods: A Companion to Methods in Enzymology, Reconstitution of Membrane Transport Proteins (ed. M.Montal), San Diego: Academic Press, Vol. 6(1) 11-17, 1994.
561. Koch, W.J., Hawes, B.E., Allen, L.F. and Lefkowitz, R.J. Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by Gbg activation of p21ras. Proc. Natl. Acad. Sci., USA, 91:12706-12710, 1994.
562. Milano, C.A., Allen, L.F., Dolber, P.C., Johnson, T.D., Rockman, H.A., Bond, R.A. and Lefkowitz, R.J. Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene. J. Thorac. and Cardiovasc. Surg., 109:236-241, 1995.
563. Stoffel, R.H., Randall, R.R., Premont, R.T., Lefkowitz, R.J. and Inglese, J. Palmitoylation of G protein-coupled receptor kinase, GRK6: Lipid modification diversity in the GRK family. J. Biol. Chem., 269:27791-27794, 1994.
564. Hawes, B.E., Touhara, K., Kurose, H., Lefkowitz, R.J. and Inglese, J. Determination of the Gbg-binding domain of phosducin: A regulatable modulator of Gbg-signaling. J. Biol. Chem., 269:29825-29830, 1994.
565. Premont, R.T., Inglese, J. and Lefkowitz, R.J. Protein kinases that phosphorylate activated G protein-coupled receptors. The FASEB J., 9:176-182, 1995.
566. Walensky, L.D., Roskams, A.J., Lefkowitz, R.J., Snyder, S.H. and Ronnett, G.V. Odorant receptors and desensitization proteins colocalize in mammalian sperm. Mol. Med., 1:130-141, 1995.
567. Inglese J., Koch, W.J., Touhara, K., and Lefkowitz, R.J. Gbg interaction: factoring in pleckstrin homology domains and Ras-MAP kinase signaling pathways, TIBS, 20:151-156, 1995.
568. Lefkowitz, R.J. Rodbell and Gilman win 1994 Nobel prize for physiology and medicine. TIPS, 15:442-444, 1994.
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570. Nair, L.A., Inglese, J., Stoffel, R., Koch, W.J., Lefkowitz, R.J., Kwatra and Grant, A.O. Cardiac muscarinic potassium channel activity is attenuated by inhibitors of Gbg. Circ. Res., 76:832-838, 1995.
571. Koch, W.J., Rockman, H.A., Samama, P., Hamilton, R.A., Bond, R.A., Milano, C.A. and Lefkowitz, R.J. Cardiac function in transgenic mice overexpressing the b-adrenergic receptor kinase or a bARK inhibitor. Science, 268:1350-1353, 1995.
572. Chen, J., DeVivo, M., Dingus, J., Harry, A., Li, J., Sui, J., Carty, D.J., Blank, J.L., Exton, J., Stoffel, R.H., Inglese, J., Lefkowitz, R.J., Logothetis, D.E., Hildebrandt, J.D., and Iyengar, R. A region of adenylyl cyclase 2 critical for regulation by G protein bg subunits. Science, 268:1166-1169, 1995.
573. Bond, R.A., Leff, P., Johnson, T.D., Milano, C.A., Rockman, H.A., McMinn, T.F., Apparsundaram, S., Hyek, M.F., Kenakin, T.P., Allen, L.F. and Lefkowitz, R.J. Physiologic effects of inverse agonists in transgenic mice with myocardial overexpression of the b2-adrenoceptor. Nature, 374:272-726, 1995.
574. Pitcher, J.A., Touhara, K., Payne, E.S. and Lefkowitz, R. J. Pleckstrin homology domain-mediated membrane association and activation of the b-adrenergic receptor kinase requires coordination with Gbg-subunits and lipid. J. Biol. Chem., 270:11707-11710, 1995.
575. Luttrell, L.M., Hawes, B.E., Touhara, K., van Biesen, T., Koch, W.J. and Lefkowitz, R.J. Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling. J. Biol. Chem., 270:12984-12989, 1995.
576. Hawes, B.E., van Biesen, T., Koch, W.J., Luttrell, L.M., Lefkowitz, R.J. Distinct pathways of Gi and Gq-mediated mitogen activated protein kinase activation. J. Biol. Chem., 270:17148-17153, 1995.
577. Pitcher, J.A., Payne, E.S., Csortos, C., DePaoli-Roach, A.A. and Lefkowitz, R.J. The G protein-coupled receptor phosphatase: A protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity. Proc. Natl. Acad. Sci., USA, 92:8343-8347, 1995.
578. Luttrell, L.M., van Biesen, T., Hawes, B.E., Koch, W.J., Touhara, K. And Lefkowitz, R.J. Gbg subunits mediate MAP kinase activation by the tyrosine kinase IGF1 receptor. J. Biol. Chem., 270:16495-16498, 1995.
579. Pei, G., Kieffer, B.L., Lefkowitz, R.J. and Freedman, N.J. Agonist-dependent phosphorylation of the mouse d-opioid receptor: Involvement of G protein-coupled receptor kinases but not protein kinase C. Mol. Pharmacol., 48:173-177, 1995.
580. Touhara, K., Koch, W.J., Hawes, B.E., and Lefkowitz, R,.J. Mutational analysis of the pleckstrin homology domain of the b-adrenergic receptor kinase: Differential effects of Gbg and phosphatidylinositol 4,5-biphosphate binding. J. Biol. Chem., 270:17000-17005, 1995.
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583. Kingsmore, S.F., Peppel, K., Suh, D., Caron, M.G., Lefkowitz, R.J. and Seldin, M.F. Genetic mapping of the beta-arrestin 1 and 2 genes on mouse chromosomes 7 and 11 respectively. Mamm. Genome. 6(4):306-7, 1995.
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585. Touhara, K., Hawes, B.E., van Biesen, T. and Lefkowitz, R.J. Gbg subunits stimulate Shc phosphorylation. Proc. Natl. Acad. Sci., USA, 92:9284-9287, 1995.
586. Hieble, J.P., Bylund, D.B., Clarke, D.E., Eikenburg, D.C., Langer, S.Z., Lefkowitz, R.J., Minneman, K.P. and Ruffolo, R.R., Jr. International Union of Pharmacology X. Recommendation for nomenclature of a1-adrenoceptors: Consensus update. Pharmacol. Rev. 47:267-270, 1995.
587. Chen, C.K., Inglese, J., Lefkowitz, R.J. and Hurley, J.B. Ca2+dependent interaction of recoverin with rhodopsin kinase. J. Biol. Chem., 270:18060-18066, 1995.
588. Van Biesen, T., Hawes, B.E., Luttrell, D.K., Krueger, K.M., Touhara, K., Porfiri, E., Sakaue, M., Luttrell, L.M. and Lefkowitz, R.J. Receptor-tyrosine-kinase- and Gbg-mediated MAP kinase activation by a common signaling pathway. Nature, 376:781-784, 1995.
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592. van Biesen, T., Hawes, B.E., Raymond, J.R., Luttrell, L.M., Koch, W.J. and Lefkowitz, R.J. Go-protein a-subunits activate mitogen-activated protein kinase via a novel PKC-dependent mechanism. J. Biol. Chem., 271:1266-1269, 1996.
593. Diversé-Pierluissi, M., Inglese, J., Stoffel, R.H., Lefkowitz, R.J. and Dunlap, K. G protein-coupled receptor kinase mediates desensitization of norepinephrine-induced calcium channel inhibition. Neuron, 16:579-585, 1996.
594. Premont, R.T., Macrae, A.D., Stoffell, R.H., Chung, N., Pitcher, J., Ambrose, C., Inglese, J., MacDonald, M.E. and Lefkowitz, R.J., Characterization of the G protein-coupled receptor kinase GRK4. J. Biol. Chem., 271:6403-6410, 1996.
595. Hoffman, B.B. and Lefkowitz, R.J. Goodman and Gilman’s The Pharmacological Basis of Therapeutics, Ninth Edition, Chapter 6, pp. 105-139. The autonomic and somatic motor nervous systems, (Eds. J.G. Hardman and L.E. Limbird, P.B. Molinoff, R.W. Ruddon, and A.G. Gilman) Macmillan Publishing Co., New York, 1996.
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597. Rockman, H.A., Hamilton, R.A., Jones, L.R., Milano, C.A., Mao, L. and Lefkowitz, R.J. Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the b2-adrenergic receptor is associated with reduced phospholamban protein. J. Clin. Invest., 97:1618-1623, 1996.
598. Tiberi, M., Nash, S.R., Bertrand, L., Lefkowitz, R.J. and Caron, M.G. Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases. J. Biol. Chem. 271:3771-3778, 1996.
599. Lefkowitz, R.J. G protein-coupled receptors and receptor kinases: From molecular biology to potential therapeutic applications. Nature Biotechnology. 14:283-286, 1996.
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602. Ménard, L., Ferguson, S.G., Barak, L.S., Bertrand, L., Premont, R.T., Colapietro, A-M., Lefkowitz, R.J. and Caron, M.G. Members of the G protein-coupled receptor kinase family that phosphorylate the b2-adrenergic receptor facilitate sequestration. Biochemistry 35:4155-4160, 1996.
603. Oppermann, M., Diversé-Pierluissi, M., Drazner, M.H., Dyer, S.L., Freedman, N.J., Peppel, K.C. and Lefkowitz, R.J. Monoclonal antibodies reveal receptor specificity among G protein-coupled receptor kinases. Proc. Natl. Acad. Sci., USA, 93:7649-7654, 1996.
604. Hawes, B.E., Luttrell, L.M., van Biesen, T. and Lefkowitz, R.J. Phosphatidylinositol 3-kinase is an early intermediate in the Gbg-mediated mitogen activated protein kinase signaling pathway. J. Biol. Chem., 271:12133-12136, 1996.
605. Pitcher, J.A., Fredericks, Z.L., Stone, W.C., Premont, R.T., Stoffel, R.H., Koch, W.J. and Lefkowitz, R.J. Phosphatidylinositol-4,5-biphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity; location, structure and regulation of the PIP2 binding site distinguishes the GRK subfamilies. J. Biol. Chem., 271:24907-24913, 1996.
606. Macrae, A.D., Premont, R.T., Jaber, M., Peterson, A.S. and Lefkowitz, R.J. Cloning, characterization and chromosomal localization of Rec1.3, a member of the G protein-coupled receptor family highly expressed in brain. Molec. Brain Res., 42:245-254, 1996.
607. Luttrell, L.M., Hawes, B.E., van Biesen, T., Luttrell, D.K., Lansing, T.J. and Lefkowitz, R.J. Role of c-Src tyrosine kinase in G protein-coupled receptor- and G bg subunit-mediated activation of mitogen activated protein kinases. J. Biol. Chem., 271:19443-19450, 1996.
608. Rockman, H.A., Choy, D-J., Rahman, N.U., Akhter, S.A., Lefkowitz, R.J. and Koch, W.J. Receptor specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. Proc. Natl. Acad. Sci., USA, 93:9954-9959, 1996.
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611. Rockman, H.A., Koch, W.J., and Lefkowitz, R.J. Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. Am. J. Physiol. 272(Heart Circ. Physiol. 41): H1553-H1559, 1997.
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613. Samama, P., Bond, R.A., Rockman, H.A., Milano, C.A. and Lefkowitz, R.J. Ligand-induced overexpression of a constitutively active b2-adrenergic adrenoceptor: Pharmacological creation of a phenotype in transgenic mice. Proc. Natl. Acad. Sci., USA, 94:137-141, 1997.
614. Rockman, H.A., Koch, W.J., Milano, C.A. and Lefkowitz, R.J. Myocardial b-adrenergic receptor signaling in vivo: Insights from transgenic mice. J. Molec. Med. 74:489-495, 1996.
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617. Luttrell, L.M., Della Rocca, G.J., van Biesen, T., Luttrell, D.K. and Lefkowitz, R.J. Gbg subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor: A scaffold for G protein-coupled receptor-mediated Ras activation. J. Biol. Chem., 272:4637-4644, 1997.
618. van Biesen, T., Luttrell, L.M., Hawes, B.E. and Lefkowitz, R.J. Mitogenic signaling via G protein-coupled receptors. Endocr. Rev., 17:698-714, 1996.
619. Garnovskaya, M.S., van Biesen, T., Hawes, B., Ramos, S.C., Lefkowitz, R.J., and Raymond, R.J. Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein bg-subunit-initiated pathway. Biochemistry 35:13716-13722, 1996.
620. Daaka, Y., Pitcher, J.A., Richardson, M., Stoffel, R.H., Robishaw, J.E. and Lefkowitz, R.J. Receptor and Gbg isoform-specific interactions with G protein-coupled receptor kinases. Proc. Natl. Acad. Sci., USA, 94:2180-2185, 1997.
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622. Drazner, M.H., Koch, W.J. and Lefkowitz, R.J. Potentiation of b-adrenergic signaling by gene transfer. Proc. Assoc. Amer. Phys., 109:220-227, 1997.
623. Sizmann, D., Kuusinen, H., Keranen, S., Lomasney, J., Caron, M.G., Lefkowitz, R.J. and Keinanem, K. Production of adrenergic receptors in yeast. Receptors and Channels 4:197-203, 1997.
624. Stoffel, III, R.H., Pitcher, J.A. and Lefkowitz, R.J. Targeting G protein-coupled receptor kinases to their receptor substrates. J. Membr. Biol. 157:1-8, 1997.
625. Menard, L., Ferguson, S.S.G., Zhang, J., Lin, F-T., Lefkowitz, R.J., Caron, M.D., Barak, L.S. Synergistic regulation of b2-adrenergic receptor sequestration: Intracellular complement of bARK and barrestin determine kinetics of internalization. Mol. Pharmacol., 51:800-808, 1997.
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627. Korzick, D.H., Xiao, R-P., Ziman, B.D., Koch, W.J., Lefkowitz, and Lakatta, E.G. Transgenic manipulation of b-adrenergic receptor kinase modifies cardiac myocyte contraction to norepinephrine. Am. J. Physiol. 272:H590-H596, 1997.
628. Freedman, N.J., Ament, A.S., Oppermann, M., Stoffel, R.H., Exum, S.T. and Lefkowitz, R.J. Phosphorylation and desensitization of human endothelin A and B receptors: Evidence for G protein-coupled receptor specificity. J. Biol. Chem., 272:17734-17743, 1997.
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636. Akhter, S.A., Skaer, C., Kypson, A.P., McDonald, P.H., Peppel, K.C., Glower, D.D., Lefkowitz, R.J. and Koch, W.J. Restoration of b-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. Proc. Natl. Acad. Sci., USA, 04:12100-12105, 1997.
637. Lin, F-T., Krueger, K.M., Kendall, H.E., Daaka, Y., Fredericks, Z.L., Pitcher, J.A. and Lefkowitz, R.J. Clathrin-mediated endocytosis of the b-adrenergic receptor is regulated by phosphorylation/ dephosphorylation of b-arrestin1. J. Biol. Chem., 272:31051-31057, 1997.
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640. Daaka, Y., Luttrell, L.M., Ahn, S., Della Rocca, G.J., Ferguson, S.S.G., Caron, M.G. and Lefkowitz, R.J. Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. J. Biol. Chem., 273:685-688, 1998.
641. Ledent, C., Denef, J-F., Cotecchia, S., Lefkowitz, R.J., Dumont, J., Vassart, G. and Parmentier, M. Costimulation of adenylyl cyclase and phospholipase C by a mutant a1B-adrenergic receptor transgene promotes malignant transformation of thyroid follicular cells. Endocrinology 138:369-378, 1997.
642. Ishizaka, N., Alexander, R.W., Laursen, J.B., Kai, H., Fukuit, T., Oppermann, M., Lefkowitz, R.J., Lyons, P.R. and Griendling, K.K. G protein-coupled receptor kinase 5 in cultured vascular smooth muscle cells and rat aorta. J. Biol. Chem. 272:32482-32488, 1997.
643. Hall, R.A., Premont, R.T., Chow, C-W., Blitzer, J.T., Pitcher, J.A., Claing, A., Stoffel, R.H., Barak, L.S., Shenolikar, S., Weinman, E.J., Grinstein, S. and Lefkowitz, R.J. The b2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. Nature, 392:626-630, 1998.
644. Della Rocca, G.J., Lefkowitz, R.J. and Koch, W.J. Methods of sequestering bg in the intact cell. In: G Proteins: Techniques of Analysis, Ed. David R. Manning, CRC Press LLC, Boca Raton, FL, pp:247-267, 1999.
645. Ford, C.E., Skiba, N.P., Bae, H., Daaka, Y., Reuveny, E., Shekter, L.R., Rosal, R., Weng, G., Yang, C-S., Iyengar, R., Miller, R.J., Jan, L.Y., Lefkowitz, R.J., and Hamm, H.E. Molecular basis for interactions of G protein bg subunits with effectors. Science, 280:1271-1274, 1998.
646. Pitcher, J.A., Hall, R.A., Daaka, Y., Zhang, J., Ferguson, S.S.G., Hester, S., Miller, S., Caron, M.G., Lefkowitz, R.J. and Blarak, L.S. The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin. J. Biol. Chem., 273:12316-12324, 1998.
647. Akhter, S.A., Luttrell, L.M., Rockman, H.A., Lefkowitz, R.J. and Koch, W.J. Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. Science, 280:574-577, 1998.
648. Davies, M.G., Huynh, T.T.T., Fulton, G.J., Lefkowitz, R.J., Svendsen, E., Hagen, P-O. and Koch, W.J. G-protein signaling and vein graft intimal hyperplasia. Reduction of intimal hyperplasia in vein grafts by a Gbg inhibitor suggests a major role of G-protein signaling in lesion development. Arterioscler. Thromb. Vasc. Biol., 18(8):1275-1280, 1998.
649. Lefkowitz, R.J. G protein-coupled receptors. New roles for receptor kinases and b-arrestins in receptor signaling and desensitization J. Biol. Chem., 273:18677-18680, 1998.
650. Koch, W.J. and Lefkowitz, R.J. Contemporary Endocrinology G-Proteins and Disease, Chapter 6, pp. 271-283. Altering adrenergic signaling and cardiac function in transgenic mice, (Ed. Allen M. Spiegel) Humana Press, Totowa, N.J., 1998.
651. Rockman, H.A., Chien, K.R., Choi, D-J., Iaccarino, G., Hunter, J.J., Ross, R., Jr., Lefkowitz, R.J. and Koch, W.J. Expression of a b-adrenergic receptor kinase1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proc. Natl. Acad. Sci., USA, 95:7000-7005, 1998.
652. Kypson, A.P., Peppel, K., Akhter, S.A., Lily, R.E., Glower, D.D., Lefkowitz, R.J. and Koch, W.J. Ex vivo adenoviral-mediated gene transfer to the transplanted adult rat heart. J. Thorac. And Cardiovascular Surg. 115:623-630, 1998.
653. Rockman, H.A., Choi, D-J., Akhter, S.A., Jaber, M., Giros, B., Lefkowitz, R.J., Caron, M.G. and Koch, W.J. Control of myocardial contractile function by the level of b-adrenergic receptor kinase1 in gene targeted mice. J. Biol. Chem., 273:18180-18184, 1998.
654. Snow, B.E., Hall, R.A., Krumins, A., Brothers, G.M., Bouchard, D., Brothers, C.A., Mangion, J., Chung, S., Gilman, A.G., Lefkowitz, R.J. and Siderovski, D.P. Characterization of RGS12: GTPase activating specificity of the RGS domain and binding specificity of an alternatively spliced PDZ domain. J. Biol. Chem., 273:17749-17755, 1998.
655. Hall, R.A., Ostegaard, L.S., Premont, R.T., Blitzer, J.T., Rahman, N., Welsh, M.J. and Lefkowitz, R.J. A carboxyl-terminal motif found in the b2-adrenergic receptor, P2Y1 receptor and CFTR determines binding to the NHERF family of PDZ proteins. Proc. Natl. Acad. Sci., 95:8496-8501, 1998.
656. Freeman, J.L.R., De La Cruz, E.M., Pollard, T.D., Lefkowitz, R.J., and Pitcher J.A. Regulation of G protein-coupled receptor kinase 5 (GRK5) by actin. J. Biol. Chem., 273:20653-20657, 1998.
657. Gaballa, M.A., Peppel, K., Lefkowitz, R.J., Aguirre, M., Dolber, P.C., Pennock, G.D., Koch, W.J., and Goldman, S. Enhanced vasorelaxation by overexpression of b2-adrenergic receptors in large arteries. J. Molec. Cell Cardiol. 30:1037-1045, 1998.
658. Iaccarino, G., Tomhave, E.D., Lefkowitz, R.J., and Koch, W.J. Reciprocal invivo regulation of myocardial G protein-coupled receptor kinase expression by b-adrenergic receptor stimulation and blockade. Circulation, 98:1783-1789, 1998.
659. Stoffel, R.H., Inglese, J., Macrae, A.D., Lefkowitz, R.J., and Premont, R.T. Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase GRK6. Biochemistry, 37:16053-16059, 1998.
660. Pitcher, J.A., Freedman, N.J., and Lefkowitz, R.J. G protein-coupled receptor kinases. Annu. Rev. Biochem. 67:653-692, 1998.
661. Xiao, R-P., Avdonin, P., Zhou, Y-Y., Cheng, H., Akhter, S.A., Eschenhagen, T., Lefkowitz, R.J., Koch, W.J. and Lakatta E.G. Coupling of b2-adrenergic receptor to GI proteins and its physiological relevance in murine cardiac myocytes. Circ. Res., 84:43-52, 1999.
662. Iaccarino, G., Dolber, P.C., Lefkowitz, R.J., and Koch, W.J. bARK1 levels in catecholamine-induced myocardial hypertrophy: Regulation by b but not a1 adrenergic stimulation. Hypertension, 33(partII) 396-401, 1999.
663. Premont, R.T., Claing, A., Vitale, N., Freeman, J.L.R., Pitcher, J.A., Patton, W.A., Moss, J., Vaughan, M. and Lefkowitz, R.J. b2-adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ARF GAP. Proc. Natl. Acad. Sci., USA, 95:14082-14087, 1998.
664. Luttrell, L.M., Ferguson, S.S.G., Daaka, Y., Miller, W.E., Maudsley, S., Della Rocca, G.J., Lin, F-T., Kawakatsu, H., Owada, K., Luttrell, D.K., Caron, M.G. and Lefkowitz, R.J. b-arrestin-dependent formation of b2-adrenergic receptor/Src kinase complexes and mitogenic signaling. Science, 283:655-661, 1999.
665. Lin, F-T., Daaka, Y. and Lefkowitz, R.J. b-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor. J. Biol. Chem. 273:31640-31643, 1998.
666. Ahn, S., Maudsley, S., Luttrell, L.M., Lefkowitz, R.J., and Daaka, Y. Src-mediated tyrosine phosphorylation of dynamin is required for b-adrenergic receptor internalization and MAPK signaling. J. Biol. Chem., 274:1185-1188, 1999.
667. Della Rocca, G.J., Mukhin, Y.V., Garnovskaya, M.N., Daaka, Y., Clark, B., Luttrell, L.M., Lefkowitz, R.J. and Raymond, J.R. Serotonin 5-HT1A receptor-mediated MAP kinase activation requires calcium/calmodulin-dependent receptor endocytosis. J. Biol. Chem., 274:4749-4753, 1999.
668. Iaccarino, G., Lefkowitz, R.J., and Koch, W.J. Myocardial G protein coupled receptor kinases: Implications for heart failure therapy. Proc. Am. Assoc. Phys., 111:399-405, 1999.
669. McDonald, P.H., Cote, H.L., Lin, F-T., Premont, R.T., Pitcher, J.A. and Lefkowitz, R.J. Identification of NSF as a b-arrestin1 binding protein; implications for b2-AR regulation. J. Biol. Chem., 274:10677-10680, 1999.
670. Kypson, A.P., Hendrickson, S.C., Akhter, S.A., Wilson, K., McDonald, P.H., Lilly, R.E., Dolber, P.C., Glower, D.D., Lefkowitz, R.J. and Koch, W.J. Adenovirus-mediated gene transfer of the b2-adrenergic receptor to donor hearts enhances cardiac function. Gene Therapy, 6:1298-1304, 1999.
671. Luttrell, L.M., Daaka, Y. and Lefkowitz, R.J. Regulation of tyrosine kinase cascades by G-protein coupled receptors. Current Opinion in Cell Biology, 11:177-183, 1999.
672. Iaccarino, G., Smithwick, L.A., Lefkowitz, R.J. and Koch, W.J. Targeting Gbg signaling in arterial vascular smooth muscle proliferation: A novel strategy to limit restenosis. Proc. Natl. Acad. Sci., USA, 96:3945-3950, 1999.
673. An, R., Heath, B.M., Higgins, J.P., Koch, W.J., Lefkowitz, R.J. and Kass, R.S. ß2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels. J. Physiol. (Lond) 516:19-30, 1999.
674. Akhter, S.A., Eckhart, A.D., Rockman, H.A., Shotwell, K., Lefkowitz, R.J. and Koch, W.J. In vivo inhibition of elevated myocardial b-adrenergic receptor kinase activity in hybrid transgenic mice restores normal b-adrenergic signaling and function. Circulation, 100:648-653, 1999.
675. Della Rocca, G.J., Maudsley, S., Daaka, Y., Lefkowitz, R.J. and Luttrell, L.M. Pleiotropic coupling of G protein-coupled receptors to the MAP kinase cascade: Role of focal adhesions and receptor tyrosine kinase. J. Biol. Chem., 274:13978-13794, 1999.
676. Walker, J.K.L., Peppel, K., Lefkowitz, R.J., Caron, M.G. and Fisher, J.T. Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3. Am. J. Physiol. 276:1214-1221, 1999.
677. Lin, F-T., Miller, W.E., Luttrell, L.M. and Lefkowitz, R.J. Feedback regulation of b-arrestin1 function by extracellular signal-regulated kinases. J. Biol. Chem., 274:15971-15974, 1999.
678. Koch, W.J., Lefkowitz, R.J. and Rockman, H.A. Functional consequences of altering myocardial adrenergic receptor signaling. Annu. Rev. Physiol., 62:237-260, 2000.
679. Maurice, J.P., Hata, J.A., Shah, A.S., White, D.C., McDonald, P.H., Dolber, P.C., Wilson, K.H., Lefkowitz, R.J., Glower, D.D. and Koch, W.J. Enhancement of cardiac function following adenoviral-mediated invivo intracoronary b2-adrenergic receptor gene delivery. J. Clin. Invest., 104:21-29, 1999.
680. Hall, R.A., Spurney, R.F., Premont, R.T., Rahman, N., Blitzer, J.T., Pitcher, J.A. and Lefkowitz, R.J. G protein-coupled receptor kinase 6A phosphorylates the Na+/H+ exchanger regulatory factor (NHERF) via a PDZ domain-mediated interaction. J. Biol. Chem., 274:24328-24334, 1999.
681. Hall, R.A., Premont, R.T. and Lefkowitz, R.J. Heptahelical receptor signaling: Beyond the G protein paradigm. J. Cell Biol, 145:927-932, 1999.
682. Premont, R.T., Macrae, A.D., Aparicio, A.A.J.R., Kendall, H.E., Welch, J.E. and Lefkowitz, R.J. The GRK4 subfamily of G protein-coupled receptor kinases: Alternative splicing, gene organization and sequence conservation. J. Biol. Chem., 274:29381-29389, 1999.
683. Pitcher, J.A. and Lefkowitz, R.J. The G protein-coupled receptor phosphatase. Regulation of G protein-coupled receptor function and expression. Ed. Jeffrey L. Benovic, Wiley-Liss, Inc., NY, NY, 179-195, 1999.
684. Pitcher, J.A., Tesmer, J.J.G., Freeman, J.L.R., Capel, W.D., Stone, W.C. and Lefkowitz, R.J. Feedback inhibition of GRK2 activity by extracellular signal-regulated kinases. J. Biol. Chem., 274:34531-34534, 1999.
685. Tang, Y., Hu, L.A., Miller, W.E., Ringstad, N., Hall, R.A., Pitcher, J.A., DeCamilli, P and Lefkowitz, R.J. Indentification of the endophelins (SH3p4/p3/p13) as novel binding partners for the b1-adrenergic receptor. Proc. Natl. Acad. Sci., USA, 96:12559-12564, 1999.
686. Gainetdinov, R.R., Bohn, L.M., Walker, J.K.L., Leporte, S.A., Macrae, A.D., Caron, M.G., Lefkowitz, R.J. and Premont, R.T. Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice. Neuron, 24:1029-1036, 1999.
687. Cross, H.R., Steenbergen, C., Lefkowitz, R.J., Koch, W.J. and Murphy E. Overexpression of the cardiac b2-adrenergic receptor and expression of a bARK1 inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury. Circ. Res., 85:1077-1084, 1999.
688. Eckhart, A.D., Duncan, S.J., Penn, R.B., Benovic, J.L., Lefkowitz, R.J. and Koch, R.J. Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases. Circ. Res., 86:43-50, 2000.
689. Lefkowitz, R.J., Rockman, H.A. and Koch, W.J. Catecholamines, cardiac "b" adrenergic receptors and heart failure. Circulation, 101:1634-1637, 2000.
690. Bohn, L.M., Lefkowitz, R.J. Gainetdinov, R.R., Peppel, K., Caron, M.D. and Lin, F-T. Enhanced morphine analgesia in mice lacking barrestin-2. Science, 286:2495-2498, 1999.
691. Claing, A., Perry, S.J., Achiriloaie, M., Walker, J.K.L., Albanesi, J.P., Lefkowitz, R.J., Premont, R. T. Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity. Proc. Natl. Acad. Sci., USA, 97:1119-1124, 2000.
692. Pierce, K.L., Maudsley, S., Daaka, Y., Luttrell, L.M. and Lefkowitz, R.J. Role of endocytosis in the activation of the ERK cascade by sequestering and non-sequestering G protein-coupled receptors. Proc. Natl. Acad. Sci., USA, 97:1489-1494, 2000.
693. Maudsley, S., Pierce, K.L., Zamah, A.M., Miller, W.E., Ahn, S., Daaka, Y., Lefkowitz, R.J. and Luttrell, L.M. The b2-Adrenergic Receptor Mediates Extracellular Signal-regulated Kinase Activation via Assembly of a Multi-receptor Complex with the Epidermal Growth Factor Receptor. J. Biol. Chem., 275:9572-9580, 2000.
694. Miller, W.E., Maudsley, S., Ahn, S., Khan, K.D., Luttrell, L.M. and Lefkowitz, R.J. b-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC: Role of b-arrestin1 dependent targeting of c-SRC in receptor endocytosis. J. Biol. Chem., 275:11312-11319, 2000.
695. Shah, A.S. Lilly E., Kypson, A.P., Tai, O., Hatta, J.A., Pippen, A., Silvestry, S.C., Lefkowitz, R.J., Glower, D. and Koch, W.J. Intracoronary adenovirus-mediated delivery and overexpression of the b2-adrenergic receptor in the heart. Prospects for molecular ventricular assistance. Circulation, 101:408-414, 2000.
696. White, D.C., Hata, J.A., Shah, A.S., Glower, D.D., Lefkowitz, R.J. and Koch, W.J. Preservation of myocardial b-adrenergic receptor signaling delays the development of heart failure following myocardial infarction. Proc. Natl. Acad. Sci., USA, 97:5428-5433, 2000.
697. Fraser, I.D.C., Cong, M., Kim, J., Rollins, E.N., Daaka, Y., Lefkowitz, R.J. and Scott, J.D. Assembly of an A kinase-anchoring protein-b2-adrenergic receptor complex facilitates receptor phosphorylation and signaling. Curr. Biol., 10:409-412, 2000.
698. Premont, R.T., Claing, A., Vitale, N., Perry, S.J. and Lefkowitz. R.J. The GIT family of ARF GTPase-activating proteins: Functional diversity of GIT2 through alternative splicing. J. Biol. Chem., 275:22373-22380, 2000.
699. Vitale, N., Patton, W.A., Moss, J., Vaughan, N., Lefkowitz, R.J. and Premont, R.T. GIT proteins, a novel family of phosphatidylinositol, 3,4,5-triphosphate-stimulated GTPase-activating proteins for ARF6. J. Biol. Chem., 275:13901-13906, 2000.
700. Zhang, S.J., Cheng, H., Zhou, Y.Y., Wang, D.J., Zhu, W., Ziman, B., Spurgeion, H., Lefkowitz, R.J., Lakatta, E.G., Koch, W.J., and Xiao, R.P. Inhibition of spontaneous b2-adrenergic activation rescues b1-adrenergic contractile response in cardiomyocytes overexpressing b2-adrenoceptor. J. Biol. Chem., 275:21773-21779, 2000.
701. Freeman, J.L.R., Pitcher, J.A., Li, X., Bennett, V. and Lefkowitz, R.J. a-Actinin is a potent regulator of G protein-coupled receptor kinase activity and substrate specificity in vitro. FEBS Letters 473:280-284, 2000.
702. Lefkowitz, R.J. The superfamily of heptahelical receptors. Nature Cell Biology 2:E132-E136, 2000.
703. Maudsley, S., Zamah, A.M., Rahman, N., Blitzer, J.T., Luttrell, L.M., Lefkowitz, R.J. and Hall, R.A. PDGF receptor association with the Na+/H+ exchanger regulatory factor (NHERF) potentiates receptor activity. Molec. and Cellular Biol., 20/22;8352-8363, 2000.
704. Hu, L.A., Tang, Y., Miller, W.E., Cong, M., Lefkowitz, R.J. and Hall. R.A. b1-adrenergic receptor association with PSD-95: Inhibition of receptor internalization and facilitation of b1-adrenergic receptor interaction with NMDA receptors. J. Biol. Chem. 275:38659-38666, 2000.
705. McDonald, P.H., Chow, C-W., Miller, W.E., Laporte, S.A., Field, M.E., Lin, F-T., Davis, R.J., and Lefkowitz, R.J. barrestin2: A receptor-regulated MAPK scaffold for the activation of JNK3. Science, 290:1574-1577, 2000.
706. Cao, W., Luttrell, L.M., Medvedev, A.V., Pierce, K.L., Daniel, K.W., Dixon, T.M., Lefkowitz, R.J., and Collins, S. Direct binding of activated c-Src to the b3-adrenergic receptor is required for MAP kinase activation. J. Biol. Chem., 275:38131-38134, 2000.
707. Shah, A.S., White, D.C., Emani, S., Kypson, A.P., Lilly, E., Wilson, K., Glower, D.D., Lefkowitz, R.J. and Koch, W.J. In vivo ventricular gene delivery of a b-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction. Circulation 103:1311-1316, 2001.
708. Bohn, L.M., Gainetdinov, R.R., Lin, F-T., Lefkowitz, R.J., and Caron, M.G. Mu opioid receptor desensitization by bArrestin2 determines morphine tolerance but not dependence. Nature 408:720-723, 2000.
709. Gainetdinov, R.R., Premont, R.T., Caron, M.G., and Lefkowitz, R.J. Receptor specificity of G-protein-coupled receptor kinases. TIPS 21:366-367, 2000.
710. Miller, W.E. and Lefkowitz, R.J. Expanding roles for b-arrestins as scaffolds/adapters in GPCR signaling and trafficking. Current Opinion in Cell Biology 13:139-146, 2001.
711. Pierce, K.L., Luttrell, L.M., and Lefkowitz, R.J. New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades. Oncogene 20:1532-1539, 2001.
712. Lefkowitz, R.J., and Willerson, J.T. Opportunities in cardiovascular research. JAMA 285:581-586, 2001.
713. Zhu, W-Z, Zheng, M., Koch, W.J., Lefkowitz, R.J., Kobilka, B.K., and Xiao, R-P. Dual modulation of cell survival and cell death by b2-adrenergic signaling in adult mouse cardiac myocytes. Proc. Natl. Acad. Sci., USA, 98:1607-1612, 2001.
714. Luttrell, L.M., Roudabush, F.L., Choy, E.W., Miller, W.E., Field, M.E., Pierce, K.L., and Lefkowitz, R.J. Activation and targeting of extracellular signal-regulated kinases by barrestin scaffolds. Proc. Natl. Acad. Sci., USA, 98:2449-2454, 2001.
715. Kohout, T.A., Lin, F-T., Perry, S.J., Conner, D.A., and Lefkowitz, R.J. bArrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proc. Natl. Acad. Sci., USA, 98:1601-1606, 2001.
716. Cong, M., Perry, S.J., Lin, F-T., Fraser, I.D., Hu, L.A., Chen, W., Pitcher, J.A., Scott, J.D., and Lefkowitz, R.J. Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79. J. Biol. Chem., 276:15192-15199, 2001.
717. Miller, W.E. and Lefkowitz, R.J. Arrestins as signaling molecules involved in apoptotic pathways: A real eye opener. Science’s STKE: http://stke.sciencemag.org/cgi/content/full/OC_sigtrans;2001/69/ pe1?ijkey=EzYNE9b31SJcI&keytype=ref&siteid=sigtrans, 2001.
718. Pierce, K.L., Tohgo, A., Ahn, S, Field, M.E., Luttrell, L.M., and Lefkowitz, R.J. Epidermal growth factor receptor dependent ERK activation by G protein-coupled receptors: A co-culture system for identifying intermediates upstream and downstream of HB-EGF shedding. J. Biol. Chem. 276:23155-23160, 2001.
719. Harding, V. B., Jones, L. R., Lefkowitz, R.J., Koch, W.J., and Rockman, H.A. Cardiac bARK1 inhibition prolongs survival and augments b blocker therapy in a mouse model of severe heart failure. Proc. Natl. Acad. Sci. USA, 98:5809-5814, 2001.
720. Freeman, K., Lerman, I., Kranias, E.G., Bohlmeyer, T., Bristow, M.R., Lefkowitz, R.J., Iaccarino, G., Koch, W.J. and Leinwand, L.A. Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. J. Clin. Invest. 107:967-974, 2001.
721. Iaccarino, G., Keys, J.R., Rapacciuolo, A., Shotwell, K.F., Lefkowitz, R.J., Rockman, H.A., and Koch, W.J. Regulation of the myocardial bARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing a1B-adrenergic receptors. J. Am. Coll. Cardiol., 38:534-540, 2001.
722. Miller, W.E., McDonald, P.H., Cai, S.F., Field, M.E., Davis, R.J., and Lefkowitz, R.J. Identification of a motif in the carboxy terminus of b-arrestin2 responsible for activation of JNK3. J. Biol. Chem., 276:27770-27780, 2001.
723. Lefkowitz, R.J. 2001: An AAP Odyssey, Association of American Physicians Presidential Address. J. Clin. Invest. , 108:S9-S13, 2001.
724. Pierce, K.L. and Lefkowitz, R.J. Classical and New Roles of b-Arrestins in the Regulation of G-Protein-Coupled Receptors. Nature Reviews: Neuroscience, 2:727-733, 2001.
725. Claing, A., Chen, W., Miller, W.E., Vitale, N., Moss, J., Premont, R.T., Lefkowitz, R.J. bArrestin-Mediated ARF6 Activation and b2-Adrenergic Receptor Endocytosis. J. Biol. Chem., 276:42509-42513, 2001.
726. Kohout, T.A., Takaoka, H., McDonald, P.H., Perry, S.J., Mao, L., Lefkowitz, R.J., Rockman, H.A. Augmentation of Cardiac Contractility Mediated by the Humanb3-Adrenergic Receptor Overexpressed in the Hearts of Transgenic Mice. Circulation, 104:2485-2491, 2001.
727. Imamura, T., Huang, J., Dalle, S., Usui, I., Ugi, S., Lefkowitz, R.J., Olefsky, J.M. b-arrestin-mediated Recruitment of the Src Family Kinase Yes Mediates Endothelin-1-stimulated Glucose Transport. J. Biol. Chem., 276:43663-43667, 2001.
728. McDonald, P.H., Lefkowitz, R.J. bArrestins: New roles in regulating heptahelical receptors’ functions. Cellular Signalling, 13:683-689, 2001.
729. Shenoy, S.K., McDonald, P.H., Kohout, T.A., Lefkowitz, R.J. Regulation of Receptor Fate by Ubiquitination of Activated b2-Adrenergic Receptor and b-Arrestin. Science, 294:1307-1313, 2001.
730. Cong, M., Perry, S.J., Hu, L.A., Hanson, P.I., Claing, A., Lefkowitz, R.J. Binding of the beta 2 adrenergic receptor to N-ethylmaleimide sensitive factor regulates receptor recycling. J. Biol.Chem., 276:45145-45152, 2001.
731. Claing, A., Laporte, S.A., Caron, M.G., Lefkowitz, R.J. Endocytosis of G Protein-Coupled Receptors: Roles of G protein-coupled receptor kinases and barrestin proteins. Progress in Neurobiology, 66:61-79, 2002.
732. Paing, M.M., Stutts, A.B., Kohout, T.A., Lefkowitz, R.J., Trejo, J. b-Arrestins Regulate Protease-activated Receptor-1 Desensitization but not Internalization or Down-regulation. J. Biol. Chem. 277:1292-1300, 2002.
733. Hu, L.A., Chen, W., Premont, R.T., Cong, M., Lefkowitz, R.J. G protein-coupled receptor kinase 5 regulates b1-adrenergic receptor association with PSD-95. J. Biol.Chem. 277:1607-1613, 2002.
734. Chen, Wei, Hu, L.A., Semenov, M.V., Yanagawa, S., Kikuchi, A., Lefkowitz, R.J., Miller, W.E. barrestin1 Modulates LEF Transcriptional Activity Through Interaction with Phosphorylated Dishevelled Proteins. Proc. Natl. Acad. Sci. USA 98:14889-14894, 2001.
735. Rockman, H.A., Koch, W.J., Lefkowitz, R.J. Seven Membrane Spanning Receptors and Heart Function. Nature 415:206-212, 2002.
736. Luttrell, L.M., and Lefkowitz, R.J. The role of b-arrestins in the termination and transduction of G-protein-coupled receptor signals. Journal of Cell Science 115: 455-465, 2002.
737. Perry, S.J. and Lefkowitz, R.J. Arresting developments in heptahelical receptor signaling and regulation. Trends in Cell Biology 12:130-138, 2002.
738. Tohgo, A., Pierce, K.L., Choy, E.W., Lefkowitz, R.J. and Luttrell, L.M. b-arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK mediated transcription following angiotensin AT1a receptor stimulation. J. Biol. Chem., 277:9429-9436, 2002.
739. Fong, A.M., Premont, R.T., Richardson, R.M., Yen-Rei, A.Y., Lefkowitz, R.J. and Patel, D.D. Defective Lymphocyte Chemotaxis in b-Arrestin2- And GRK6-Deficient Mice. Proc. Natl. Acad. Sci. USA 989: 7478-7483, 2002.
740. Ahn, S., Kim, J., Lucaveche, C.L., Reedy, M.C., Luttrell, L.M., Lefkowitz, R.J. and Daaka, Y. Src-dependent Tyrosine Phosphorylation Regulates Dynamin Self-assembly and Ligand-Induced Endocytosis of the Epidermal Growth Factor Receptor. J. Biol. Chem. 277:26642-26651, 2002.
741. Eckhart, A., Fentzke, R.C., Lepore, J., Lang, R., Lin, H., Lefkowitz, R.J., Koch, W.J. and Leiden, J.M. Inhibition of bARK1 Restores Impaired Biochemical b-Adrenergic Receptor Responsiveness but does not Rescue CREDA133 Induced Cardiomyopathy, J. Mol. Cell Cardiol., 34, 669-677, 2002.
742. Zamah, A.M., Delahunty, M., Luttrell, L.M., Lefkowitz, R.J. PKA-Mediated Phosphorylation of the b2-Adrenergic Receptor Regulates its Coupling to Gs and Gi: Demonstration in a Reconstituted System. J. Biol. Chem. 277:31249-31256, 2002.
743. Lin, F.T., Chen, W., Shenoy, S., Cong, M., Exum, S.T. and Lefkowitz, R.J. Phosphorylation of b-Arrestin2 Regulates Its Function in Internalization of b2-Adrenergic Receptors. Biochemistry 41:10692-10699, 2002.
744. Lefkowitz, R.J., Pierce, K.L. and Luttrell, L.M. Dancing with Differeint Partners: PKA Phosphorylation of Seven Membrane Spanning Receptors Regulates Their G Protein Coupling Specificity , Molecular Pharmacology 62:971-974, 2002.
745. Pierce, K.L., Premont, R.T. and Lefkowitz, R.J. Seven Transmembrane Spanning Receptors, Nature Rev. Molec. Cell. Biol. 3:639-650, 2002.
746. Perry, S.J., Baillie, G.S., Kohout, T.A., McPhee, I., Magiera, M.M., Ang, K.L., Miller, W.E., McLean, A.J., Conti, M., Houslay, M.D. and Lefkowitz, R.J. Targeting of cyclic AMP degradation to b2-adrenergic receptors by b-arrestins. Science, 298:834-836, 2002.
747. Freeman, J.L.R., Gonzalo, P., Pitcher, J.A., Claing, A., Lavergne, J-P, Rebous, J-P and Lefkowitz, R.J. b2-Adrenergic Receptor Stimulated, G protein Coupled Receptor Kinase 2 mediated, phosphorylation of Ribosomal Protein P2, Biochemistry 41:12850-12857, 2002.
748. Hall, R.A. and Lefkowitz, R.J. Regulation of G protein-Coupled Receptor Signaling by Scaffold Proteins, Circ. Res., 91:672-680, 2002.
749. Bohn, Laura M., Lefkowitz, Robert J., Caron, Marc G. Differential Mechanisms of Morphine Antinociceptive Tolerance Revealed in barrestin-2 Knockout Mice, J. Neurosci., 22(23):10494-10500, 2002.
750. Kohout, T.A. and Lefkowitz, R.J. Regulation of G protein-Coupled Receptor Kinases and Arrestins During Receptor Desensitization. Molecular Pharmacology, 63:9-18, 2003.
751. Hanyaloglu, A.C., Seeber, R.M., Kohout, T.A., Lefkowitz, R.J. and Eidne, Karin A. Homo and heter-oligomerization of thyrotropin releasing hormone (TRH) receptor subtypes: Differential regulation of b-arrestins 1 and 2, J. Biol. Chem., 277:50422-50430, 2002.
752. Tohgo, A., Choy, E.W., Gesty-Palmer, D., Pierce, K.L., Laporte, S., Oakley, R.H., Caron, M.G., Lefkowitz, R.J. and Luttrell, L.M. The Stability of the G Protein-Coupled Receptor-b-arrestin Interaction Determines the Mechanism and Functional Consequence of ERK Activation, J.Biol. Chem., 278:6258-6267, 2003.
753. Baillie, G.S., Sood, A. McPhee, I., Gall, I., Perry, S.J., Lefkowitz, R.J. and Houslay, M.D. b-arrestin mediated PDE4 phosphodiesterase recruitment regulates b-adrenoceptor switching from Gs to Gi, Proc. Natl. Acad. Sci. USA, 100:940-945, 2003.
754. Ahn, S., Nelson, C.D., Garrison, F.R., Miller, W.E. and Lefkowitz, R.J. Desensitization, Internalization and Signaling Functions of b-arrestins Demonstrated by RNA Interference, Proc. Natl. Acad. Sci. USA, 100:1740-1744, 2003.
755. Shenoy, S.K. and Lefkowitz, R.J. Trafficking patterns of b-arrestin and G-Protein-Coupled Receptors determined by the kinetics of b-arrestin deubiquitination, J. Biol. Chem., 278:14498-14506, 2003.
756. Lefkowitz, R.J. A Magnificent Time with the “Magnificent Seven” Transmembrane Spanning Receptors, Circ. Res. 92(4):342-344, 2003.
757. Lodowski, D.T., Pitcher, J.A., Capel. W.D., Lefkowitz, R.J. and Tesmer, J.J.G. Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gbg, Science, 300:1256-1262, 2003.
758. Miller, W.E., Houtz, D.A., Nelson, C.D., Kolattukudy, P.E. and Lefkowitz, R.J. GRK Phosphorylation and barrestin Recruitment Regulate the Constitutive Signaling Activity of the Human Cytomegalovirus US28 GPCR, J. Biol. Chem. 278(24):21633-21671, 2003.
759. Hu, L.A., Chen, W., Whalen, E., Premont, R. and Lefkowitz, R.J. GIPC interacts with the b1- adrenergic receptor and regulates b1-adrenergic receptor mediated ERK activation, J. Biol. Chem., 278(28):26295-26301, 2003.
760. Lodowski, D.T., Barnhill, J.F., Pitcher, J.A., Capel, W.D., Lefkowitz, R.J. and Tesmer, J.J.G. Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gb1g2. Acta Crystallogr D Biol Crystallogr, D59:936-939, 2003.
761. Gainetdinov, R.R., Bohn, L.M., Sotnikova, T.D., Cyr, M., Laakso, A., Macrae, A.D., Torres, G.E., Kim, K-M., Lefkowitz, R.J., Caron, M.G. and Premont, R.T. Dopaminergic Supersensitivity in G Protein-Coupled Receptor Kinase 6-Deficient Mice. Neuron, 38:291-303, 2003.
762. Chen, W., ten Berge, D., Brown, J., Ahn, S., Hu, L.A., Miller, W.E., Caron, MC., Barak, LS., Nusse, R. and Lefkowitz, R.J. Dishevelled2 Recruits barrestin2 to mediate Wnt5A-Stimulated Endocytosis of Frizzled. Science, 301:1391-1394, 2003.
763. Walker, J.K.L., Fong, A.M., Lawson, B.L., Savov, J.D., Patel, D.D., Schwartz, D.A. and Lefkowitz, R.J. b-arrestin-2 regulates the development of allergic asthma. J. Clin. Invest., 112:566-574, 2003.
764. Rapacciuolo, A., Suvarna, S., Barki-Harrington, L., Luttrell, L.M., Cong, M., Lefkowitz, R.J. and Rockman, H.A. PKA and GRK phosphorylation mediate b-1 adrenergic receptor endocytosis through different pathways. J. Biol. Chem., 278:35403-35411, 2003.
765. Wei, H., Ahn, S., Shenoy, S.K., Karnik, S.S., Hunyady, L., Luttrell, L.M. and Lefkowitz, R.J. Independent b-Arrestin2 and G protein mediated pathways for angiotensin II activation of ERK1/2. Proc. Natl. Acad. Sci. USA, 100:10782-10787, 2003.
766. Chen, W., Kirkbride, K.C., How, T., Nelson, C.D., Mo, J., Frederick, J.P., Wang, X-F., Lefkowitz, R.J. and Blobe, G.C. b-Arrestin2 mediates endocytosis of type III TGF-b receptor and down regulation of its signaling. Science, 301:1394-1397, 2003.
767. Vines, C.M., Revankar, C.M., Maestas, D.C., LaRusch, L.L., Cimino, D.F., Kohout, T.A., Lefkowitz, R.J. and Prossnitz, E.R. N-formyl Peptide Receptors Internalize but do not recycle in the Absence of Arrestins. J. Biol. Chem., 278:41581-41584, 2003.
768. Shenoy, S.K. and Lefkowitz, R.J. Multifaceted roles of b-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling. Biochem. J., 375:503-515, 2003.
769. Martin, N.P., Lefkowitz, R.J. and Shenoy, S.K. Regulation of V2 Vasopressin Receptor Degradation by Agonist Promoted Ubiquitination. J. Biol. Chem., 278:45954-45959, 2003.
770. Terman, GW, Jin, W, Cheong Y-P, Lowe, J, Caron, MG, Lefkowitz, RJ and Chavkin, C. G-Protein Receptor Kinase 3 (GRK3) Influences Opioid Analgesic Tolerance but not Opioid Withdrawal. Br. J. Pharmacol., 141:55-64, 2004
771. Walker, J.K.L., Gainetdinov, R.R., Feldman, D.S., Fawn, P.K., Caron, M.G., Lefkowitz, R.J., Premont, R.T. and Fisher, J.T. G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation, Am. J. Physiol. Lun Cell Mol. Physiol, 286:L312-319, 2004.
772. Kavelaars, A., Vroon, A., Raatgever, R., Fong, A.M., Premont, R., Patel, D.D., Lefkowitz, R.J. and Heijnen, C.J. Increased acute inflammation, leukotriene B4-induced chemotaxis and signaling in mice deficient for G Protein-Coupled Receptor Kinase 6 J. Immunol., 171: 6128-6134, 2003.
773. Povsic, T.J., Kohout, T.A. and Lefkowitz, R.J. b-Arrestin1 mediates IGF-1 stimulated activation of PI-3-K and anti-apoptosis. J. Biol. Chem., 278:51334-51339, 2003.
774. McLaughlin, J.P., Myers, L.C., Zarek, P.E., Caron, M.G., Lefkowitz, R.J., Czyzyk, T.A., Pintar, J.E. and Chavkin, C. Prolonged ?-opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance. J. Biol. Chem., 279:1810-1818, 2004.
775. Bohn, L.M., Gainetdinov, R.R., Sotnikova, T.D., Medvedev, I.O., Lefkowitz, R.J., Dykstra, L.S. and Caron, M.G. Enhanced Rewarding Properties of Morphine, but not Cocaine, in b-arrestin-2 Knock-out Mice. J. Neurosci., 23:10265-10273, 2003.
776. Ahn, S., Wei, H., Garrison, T.R. and Lefkowitz, R.J. Reciprocal Regulation of Angiotensin Receptor-activated Extracellular Signal-regulated Kinases by b-Arrestins 1 and 2. J. Biol. Chem., 279:7807-7811, 2004.
777. Gainetdinov, R.R., Premont, R.T., Bohn, L.M., Lefkowitz, R.J. and Caron, M.G. Desensitization of G Protein-Coupled Receptors and Neuronal Functions, Annu. Rev. Neurosci. 27:107-44, 2004.
778. Fukuto, H.S., Ferkey, D.M., Apicella, A.J., Lans, H., Sharmeen, T., Chen, W., Lefkowitz, R.J., Jansen, G., Schafer, W.R. and Hart, A.C. G Protein-coupled receptor kinase function is essential for Chemosensation in C. elegans. Neuron 27: 581-593, 2004.
779. Freedman, N.J. and Lefkowitz, R.J. Anti-b1-adrenergic receptor antibodies and heart failure: causation, not just correlation. J. Clin. Invest. 113: 1379-1382, 2004.
780. Galliera, E., Jala, V.R., Trent, J.O., Bonecchi, R., Signorelli, P., Lefkowitz, R.J., Mantovani, A., Locati, M., Haribabu, B. b-Arrestin dependent constitutive internalization of the human chemokine decoy receptor D6. J. Biol. Chem. 279: 25590-25597, 2004.
781. Lefkowitz, R.J. Forward to "G Protein Coupled Receptor-Protein Interactions". (S. R.George and B.F. O'Dowd, Eds). John Wiley & Sons, page ix, 2005.
782. Martin, N.P., Whalen, E.J., Zamah, M.A., Pierce, K.L. and Lefkowitz, R.J. PKA mediated phosphorylation of the b1-adrenergic receptor promotes Gs/Gi switching. Cellular Signalling 16: 1397-1403, 2004
783. Witherow, D.S., Garrison, T.R., Miller, W.E. and Lefkowitz, R.J. b-arrestin inhibits NFkB activity via its interaction with the NFkB inhibitor IkBa. Proc. Natl. Acad. Sci. USA 101: 8603-8607, 2004.
784. Tachibana, H., Prasad, S.V.N., Lefkowitz, R.J., Koch, W.J. and Rockman, H.A. Level of bARK1 inhibition determines the degree of cardiac dysfunction following chronic pressure overload induced heart failure. Circulation, in press, 2004.
785. Xu, M., Petraschka, M., McLaughlin, J.P., Westenbroek, R.E., Caron, M.G., Lefkowitz, R.J., Czyzyk, T.A., Pintar, J.E., Terman, G.W. and Chavkin, C. Neuropathic pain activates the endogenous k opioid system in mouse spinal cord and induces opioid receptor tolerance. Journal of Neuroscience 24, 4576-4584, 2004.
786. Lefkowitz, R.J. and Whalen, E.J. b-arrestins: traffic cops of cell signaling. Current Opinion in Cell Biology 16, 1-7, 2004.
787. Wang, Q., Zhao, J., Brady, A.E., Feng, J., Allen, P.B., Lefkowitz, R.J., Greengard, P. and Limbird, L.E. Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science, 304:1940-1944, 2004.
788. Bond, R.A. and Lefkowitz, R.J. "GPCRs as Drug Targets - Analysis of Activation and Constitutive Activity". Historical Background. Seifert, Wieland (Eds.) (Series: Methods and Principles in Medicinal Chemistry. Series editors: R. Mannhold, H. Kubinyi, G. Folkers), Wiley-VCH publishers, in press, 2005.
789. Bohn, L.M., Dykstra, L.A., Lefkowitz, R.J., Caron, M.G. and Barak, L.S. Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery. Mol. Pharmacol. 66: 106-112, 2004.
790. Ahn, S., Shenoy, S.K. Wei, H. and Lefkowitz, R.J. Differential kinetic and spatial patterns of b-arrestin2 and G protein-mediated ERK activated by the angiotensin II receptor. J. Biol. Chem. 279: 35518-35525, 2004
791. Dinudom, A., Fotia, A.B., Lefkowitz, R.J., Young, J.A., Kumar, S, and Cook, D.I. The Kinase Grk2 regulates Nedd4/Nedd4-dependent control of epithelial Na+ channels. Proc. Natl. Acad. Sci. 101: 11886-11890, 2004.
792. Usui, I., Imamura, T., Huang, J., Satoh, H., Shenoy, S.K., Lefkowitz, R.J., Hupfeld, C.J. and Olefsky, J.M. b-Arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate-1. Mol. Cell Biol. 24: 8929-8937, 2004.
793. Lefkowitz, R.J. Historical review: A brief history and personal retrospective of seven-transmembrane receptors. Trends in Pharmacological Sciences 25/8: 413-422, 2004.
794. Wei, H., Ahn, S., Barnes, W.G. and Lefkowitz, R.J. Stable interaction between b-arrestin 2 and AT1A receptor is required for b-arrestin 2 mediated activation of extracellular signal-regulated kinase 1 and 2. J, Biol. Chem. 279: 48255-48261, 2004.
795. Ge, L., Shenoy, S.K., Lefkowitz, R.J., DeFea, K.A. Constitutive protease-activated receptor-2 mediated migration of MDA MB-231 breast cancer cells requires both b-arrestin-1 and 2. J. Biol. Chem. 279: 55419-55424, 2004.
796. Xiao, K., Shenoy, S.K., Nobles, K., and Lefkowitz, R.J. Activation Dependent Conformational Changes in ß-arrestin2. J. Biol. Chem.279: 55744-55753, 2004.
797. Shenoy, S.K. and Lefkowitz, R.J. Resonating to the music of Ubiquitination. News and Views. In Nature Methods 1:191-193, 2004.
798. Chen, W., Ren, X, Nelson, C.D., Barak, L.S., Chen, J.K., Beachy, PA., de Sauvage, F., and Lefkowitz, R.J. Activity-Dependent Internalization of Smoothened Mediated ß-arrestin 2 and GRK2, Science, 306:2257-2260, 2004.
799. Kim, J., Ahn, S., Ren, X-R., Whalen, E., Reiter, E., Wei, H. and Lefkowitz, R.J. Functional antagonism of different G protein-coupled receptor kinases for ß-arrestin-mediated angiotensin II Receptor signaling. Proc. Natl. Acad. Sci. USA 102: 1442-1447, 2005.
800. Ren, X-R., Reiter, E., Ahn, S., Kim, J., Chen, W. and Lefkowitz, R.J. Different G protein-coupled receptor kinases goven G protein and ß-arrestin-mediated signaling of V2 vasopressin receptor. Proc. Natl. Acad. Sci. USA 102: 1448-1453, 2005.
801. Hunton, D.L., Barnes, W.G., Kim, J., Ren, X-R, Violin, J.D., Reiter E., Milligan, G., Patel, D. and Lefkowitz, R.J. ß-Arrestin 2 dependent AT1A receptor mediated pathway of chemotaxis uncoupled from G protein Signaling. Mol. Pharmacol. 67: 1229-1236, 2005.
802. Barnes, W.G., Reiter, E., Violin, J.D., Ren, X-R., Milligan, G. and Lefkowitz, R.J. ß-Arrestin1 and Gaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J. Biol. Chem., 280:8041-8050, 2005.
803. Milasta, S., Evans, N.A., Ormiston, L, Wilson, S., Lefkowitz, R.J., and Milligan, G. The affinity of interactions between the orexin-1 receptor and ß-arrestin-2 determines the kinetics of ERK MAP kinase regulation and is defined by a single C-terminal cluster of hydroxyl amino acids. Biochem. J. 387:573-584, 2005.
804. Lefkowitz, R.J. and Shenoy, S.K. Transduction of Receptor Signals by ß-arrestins. Science 308: 512-517, 2005.
805. Shenoy, S.K. and Lefkowitz, R.J. Receptor-specific ubiquitination of ß-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. J. Biol. Chem. 280: 15315-15324, 2005.
806. Girnita, L., Shenoy, S.K., Schat, B., Vasilcanu, R., Girnita, A, Lefkowitz, R.J. and Larsson, O. ß-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J. Biol. Chem., in press, 2005.
807. Jean-Martin Beaulieu, Tatyana D. Sotnikova, Sebastien Marion, Robert J. Lefkowitz, Raul R. Gainetdinov, Marc G. Caron. A ß-arrestin 2/Akt/PAP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell, 122:261-273, 2005.
808. Summary of Wenner-Gren international symposium receptor-receptor interactions among heptaspanning membrane receptors: from structure to function. J Mol Neurosci. 26(2-3):293-4, 2005.
809. Shenoy, S.K. and Lefkowitz, R.J. Seven-Transmembrane Receptor Signaling Though ß-Arrestin. Science, STKE: www.stke.org/cgi/content/full/sigtrans;205/208/cm10.
810. Shenoy, S.K. and Lefkowitz, R.J. Receptor regulation: ß-arrestin moves up a notch. Nature Cell Biology 7: 1159-1161, 2005.
811. Rajagopal, K., Lefkowitz, R.J. and Rockman, H.A. When 7 transmembrane receptors are not G protein-coupled receptors. J. Clin. Invest. 115: 2971-2974, 2005.
812. Shenoy, S.K., Drake, M.T., Nelson, C.D., Houtz, D.A., Xiao, K., Madabushi, S., Reiter, E., Premont, R.T., Lichtarge, O. and Lefkowitz, R.J. ß-arrestin-dependent G Protein-independent ERK 1/2 Acitivation by the ß_2-adrenergic receptor. J. Biol. Chem. 281: 1261-1273, 2006.
813. Gesty-Palmer, G., Chen, M., Reiter, E., Ahn, S., Nelson, C.D., Loomis, C.R., Spurney, R.F., Luttrell, L.M., and Lefkowitz, R.J. Distinct ß-arrestin and G protein dependent pathways for parathyroid hormone receptor-stimulated ERK 1/2 activation. J. Biol. Chem. 281: 10856-10864, 2006.
814. Reiter, E. and Lefkowitz, R.J. GRKs and beta-arrestins: roles in receptor silencing, traffcking and signaling. Trends in Endocrinology and Metabolism 17: 159-165, 2006.
815. Violin, J.D., Ren, X-R and Lefkowitz, R.J. GRK specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. J. Biol. Chem. 281: 20577-20588, 2006.
816. Meloni, A.R., Fralish, G.B., Kelly, P., Salahpour, A., Chen, J.K., Wechsler-Reya, R.J., Lefkowitz, R.J., Caron, M.G. Smoothened Signal Transduction is Promoted by G-Protein Coupled Receptor Kinase 2. Molecular and Cellular Biology 26: 7550-7560, 2006.
817. Drake, M.T., Shenoy, S.K. and Lefkowitz, R.J. Trafficking of G Protein – Coupled Receptors. Circ. Res. 99:570-582, 2006.
818. Lefkowitz, R.J., Rajagopal, K. and Whalen, E.J. New Roles for ß-Arrestins in Cell Signaling: Not Just for Seven Transmembrane Receptors. Molecular Cell, 24:643-652, 2006.
819. Rajagopal, K., Whalen, E.J., Violin, J.D., Stiber, J.A., Rosenberg, P.B., Premont, R.T., Coffman, T.M., Rockman, H.W., and Lefkowitz, R.J. ß-arrestin2-Mediated Inotropic Effects of the Angiotensin II Type 1A Receptor in Isolated Cardiac Myocytes. Proc. Natl. Acad. Sci. 103:16284-16289, 2006.
820. Violin, J.D., DeWire, S.M., Barnes, W.G., and Lefkowitz, R.J. GRK and ß-arrestin Mediated Desensitization of the Angiotensin II Type 1A Receptor Elucidated by Diacylglycerol Dynamics. J. Biol. Chem. 281:36411-36419, 2006.
821. Lefkowitz, R.J. Seven Transmembrane Receptors – A Brief Personal Retrospective. Biochemica et Biophysica Acta 1768: 748-755, 2007.
822. Nelson, C.D., Perry, S.J., Regier, D.S., Prescott, S.M., Topham, M.K. and Lefkowitz, R.J. Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by ß-arrestins. Science 315: 663-666, 2006.
823. Girnita, L., Shenoy, S.K., Sehat, B., Vasilcanu, R., Vasilcanu, D., Girnita, A., Lefkowitz, R.J., and Larsson, O. ß-arrestin and Mdm2 mediated IGF-1 receptor stimulated ERK activation and cell cycle progression. J. Biol. Chem. 282: 11329-11338, 2007.
824. Violin, J.D. and Lefkowitz, R.J. ß-Arrestin-Biased Ligands at Seven-Transmembrane Receptors. Trends in Pharmacological Sciences 28:416-422, 2007.
825. Whalen, E.J., Foster, MW, Matsumoto, A, Ozawa, K, Violin, J.D., Que, L.G., Benhar, M., Keys, J.R., Koch, W.J., Daaka, Y., Lefkowitz, R.J., and Stamler, J.S. Regulation of ß-adrenergic receptor Signaling by S-nitrosylation of G Protein-Couple Receptor Kinase 2. Cell 129:511-522, 2007.
826. DeWire, S.M., Ahn, S., Lefkowitz, R.J., and Shenoy, S.K. ß-arrestins and Cell Signaling. Annu Rev. Physiology 69:483-510, 2007.
827. Lefkowitz, R.J. Seven Transmembrane receptors: something old, something new. Acta Physiologica 190:9-19, 2007.
828. Nobles, K.N., Ziqiang G., Kunhong, X, Oas T.G., and Lefkowitz, R.J. The Active Confrontation of ß-arrestin1: Direct Evidence for the Phosphate Sensor in the N-domain and Conformational Differences in the Active States of ß-arrestins1 and 2. J. Biol. Chem. 282:21370-21380, 2007.
829. Xiao, K., McClatchy, D.B., Shukla, A.K., Zhao, Y., Chen, M., Shenoy, S.K., Yate, J.R., and Lefkowitz, R.J. Functional Specialization of ß-arrestin Interactions Revealed by Proteomic Analysis. Proc. Natl. Acad. Sci., USA, 104:12011-12016, 2007.
830. Noma, T., Lemaire, A., Prasad, S.V.N., Barki-Harrington, L., Tilley, D.G., Chen, J., Corvoisier P., Violin, J.D., Wei, H., Lefkowitz, R.J. and Rockman, H.A. ß-Arrestin mediated ß1-adrenergic receptor transactivation of the epidermal growth factor receptor confers cardioprotection. J. Clin. Invest. 117:2445-2458, 2007.
831. Shenoy, S.K., Barak, L.S., Xiao, K., Ahn, S., Luttrell, L.M., and Lefkowitz, R.J. Ubiquitination of ß-arrestin links 7-transmembrane receptor endocytosis and ERK activation. J. Biol. Chem. 282:29549-29562, 2007.
832. Wisler, J.W, DeWire, S.M, Whalem, E.J, Violin, J.D, Drake, M.T, Ahn, S., Shenoy, S.K, and Lefkowitz, R.J. A novel mechanism of beta blocker action: carvedilol stimulates ß-arrestin signaling. Proc. Natl. Acad. Sci., 104:16657-16662, 2007.
833. Beaulieu, J-M., Marion, S., Rodriguiz, R.M., Medvedev, I.O., Sotnikova, T.D., Ghisi, V., Wetsel, W.C., Lefkowitz, R.J., Gainetdinov, R.R. and Caron, M.G. A ß-arrestin 2 signaling complex mediates lithium action in vivo. Cell 132: 125-136, 2008.
834. Violin, J.D., DiPilato, L.M., Yildirim, N., Elston, T.C., Zhang, J. and Lefkowitz, R.J. ß2-Adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real-time cAMP dynamics. J. Biol. Chem. 283: 2949-2961, 2008.
835. Lefkowitz, R.J. The Annual ASCI Meeting: Does Nostalgia Have a Future? J. Clin. Invest. 118: 1231-1233, 2008.
836. Drake, M.T., Violin, J.D., Whalen, E.J., Wisler, J.W., Shenoy, S.K. and Lefkowitz, R.J. ß-Arrestin-Biased Agonism at the ß2-Adrenergic Receptor. J. Biol. Chem. 283:5669-5676, 2008.
837. Lefkowitz, R.J., Sun, J-P, Shukla, A.K. A Crystal Clear View of the ß2-Adrenergic Receptor. Nature Biotechnology 26: 189-191, 2008.
838. DeWire, S.M., Kim, J., Whalen, E.J., Ahn, S., Chen, M. and Lefkowitz, R.J. ß-Arrestin-mediated Signaling Regulates Protein Synthesis. J. Biol. Chem. 283: 10611-10620, 2008.
839. Shukla, A.K., Violin, J.D., Whalen, E.J., Gesty-Palmer, D., Shenoy, S.K. and Lefkowitz, R.J. Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors. Proc. Natl. Acad. Sci. USA, 105: 9988-9995, 2008.
840. Kovacs, J.J., Whalen, E.J., Liu, R., Xiao, K., Kim, J., Chen, M., Wang, J., Chen, W. and Lefkowitz, R.J. Beta-arrestin mediated localization of smoothened to the primary cilium. Science 320: 1777-1781, 2008.
841. Ozawa, K., Hess, D.T., Lefkowitz, R.J. and Stamler, J.S. S-nitrosylation of ß-arrestin regulates ß-adrenergic receptor trafficking. Molecular Cell 31: 395-405, 2008.
842. Kim, J., Zhang, L., Peppel, K., Wu, J-H, Zidar, D.A., Brian, L., DeWire, S.M., Lefkowitz, R.J., and Freedman, N.J. ß-arrestins Regulate Atherosclerosis and Neointimal Hyperplasia by Controlling Smooth Muscle Cell Proliferation and Migration. Circulation Research 103: 70-79, 2008.
843. Berak, L.S., Salapour, A., Zhang, X., Masri, B., Sotnikova, T.D., Ramsey, A.J., Violin, J.D., Lefkowitz, R.J., Caron, M.G., and Gainetdinov, R.R. Pharmacological characterization of membrane-expressed human trace amine associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer (BRET) cAMP biosensor. Mol. Pharm. 74: 585-594, 2008.
844. Nelson, C.D., Kovacs, J.J., Nobles, K.N., Whalen, E.J. and Lefkowitz, R.J. ß-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase lα promotes agonist-stimulated sequestration of the β-2-adrenergic receptor. J. Biol. Chem. 283: 21093-21101, 2008.
845. Shukla, A.K., Sun, J.P. and Lefkowitz, R.J. Cystallizing thinking about the beta2-adrenergic receptor. Mol. Pharmacol. 73: 1333-1338, 2008.
846. Tarrant, T.K., Rampersad, R.R., Esserman, D., Rothlein, L.R., Liu, P., Premont, R.T., Lefkowitz, R.J., Lee, D.M. and Patel, D.D. Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). Clinical Immunology 129: 115-122, 2008.
847. Ahn, S., Kim, J., Hara, M.R., Ren, X-R. and Lefkowitz, R.J. β-Arrestin-2 Mediates Anti-Apoptotic Signaling Through Regulation of BAD Phosphorylation. J. Biol. Chem. 284: 8855-8865, 2009.
848. Shenoy, S.K., Modi, A.S., Shukla, A., Xiao, K., Berthouze, M., Ahn, S., Wilkinson, K.D., Miller, W.E. and Lefkowitz, R.J. β-Arrestin-dependent signaling and trafficking of 7TMRs is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proc. Natl. Acad. Sci. USA 106: 6650-6655, 2009.
849. Walters, R.W., Shukla, A.K., Kovacs, J.J., Violin, J.D., DeWire, S.M., Lam, C.M., Chen, J.R., Muehlbauer, M.J., Whalen, E.J. and Lefkowitz, R.J. β-arrestin1 Mediates nicotinic acid induced flushing, but not its antilipolytic effect. J. Clin. Invest. 119: 1312-1321, 2009.
850. Kim, J., Ahn, S., Rajapopal, K. and Lefkowitz, R.J. Independent β-Arrestin2 and Gq/PKCζ Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the EGFR. J. Biol. Chem. 284: 11953-11962, 2009.
851. Zidar, D.A., Violin, J.D., Whalen, E.J. and Lefkowitz, R.J. Selective Engagement of G protein-coupled Receptor Kinase (GRKs) encodes distinct functions of biased ligands. Proc. Natl. Acad. Sci. USA 106: 9649-9654, 2009.
852. Gesty-Palmer, D., Flannery, P., Yuan, L., Corsino, L., Spurney, R., Lefkowitz, R.J. and Luttrell, L.M. A β-Arrestin Biased Agonist of the Parathyroid Hormone Receptor (PTH1R) Promotes Bone Formation Independent of G Protein Activation. Science Translational Medicine 1: 1-9, 2009. Abstract | Full Text
853. Xie, L., Xiao, K., Whalen, E.J., Forrester, M.T., Gygi, S.P., Lefkowitz, R.J. and Stamler, J.S. Oxygen-regulated β2-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation. Science Signaling, in press, 2009.
854. Chen, M., Philipp, M., Wang, J., Premont, R.T., Garrison, T.R., Caron, M.G., Lefkowitz, R.J. and Chen, W. G Protein-coupled Receptor Kinases Phosphorylate LRP6 in the Wnt Pathway. J. Biol. Chem., in press, 2009.