Howard Hughes Medical Institute
Duke University Medical Center
Durham, North Carolina
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Hara, M.R., Kovacs, J.J., Whalen, E.J., Rajagopal, S., Strachan, R.T., Grant, W., Towers, A.J., Williams, B., Lam, C.M., Xiao, K., Shenoy, S.K., Gregory, S.G., Ahn, S., Duckett, D.R. and Lefkowitz, R.J.  Stress Response Pathway Regulates DNA Damage Through β2-Adrenoreceptors and β-Arrestin-1.  Nature 477: 349-353, 2011. PMID: 21857681 [PubMed - in process]


Reiter, E., Ahn, S., Shukla, A.K. and Lefkowitz, R.J.  Molecular mechanisms of β-arrestin-biased agonism at seven transmembrane receptors.  Ann. Review of Pharmacology and Toxicology 52: 179-197, 2011.


Shukla, A.K., Xiao, K., and Lefkowitz, R.J.  Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling.  Trends in Pharmacological Sciences 36: 457-469, 2011.

Nobles, K., Xiao, K., Ahn, S., Shukla, A.K., Lam, C.M., Rajagopal, S., Strachan, R.T., Huang, T-Y., Bressler, E.A., Hara, M.R., Shenoy, S.K., Gygi, S.P. and Lefkowitz, R.J.  Distinct G Protein-Coupled Receptor Kinase Phosphorylation Sites on the β-Adrenergic Receptor: A Bar Code for Differential Encoding of β-Arrestin Functions.  Science Signaling 4: 1-10, 2011.


Kahsai, A.W., Xiao, K., Rajagopal, S., Ahn, S., Shukla, A.K., Sun, J., Oas, T.G. and Lefkowitz, R.J.  Multiple Ligand-Specific Conformations of the β2-Adrenergic Receptor.  Nature Chemical Biology, 7: 692-700, 2011. PMID: 21857662 [PubMed - in process]


Rockman, H.A. and Lefkowitz, R.J.  Introduction to the Series on Novel Aspects of Cardiovascular G-Protein-Coupled Receptor Signaling.  Circ. Res. 109: 202-204,2011.


Rajagopal, S., Ahn, S., Rominger, D.H., Gowen-McDonald, W., Lam, C.M., DeWire, S.M., Violin, J.D. and Lefkowitz, R.J.  Quantifying Ligand Bias at Seven-Transmembrane Receptors.  Mol. Pharmacol. 80: 367-377,2011. PMCID: PMC3164332


Shenoy, S.K. and Lefkowitz, R.J.  β-Arrestin-mediated receptor trafficking and signal transduction.  Trends in Pharmacological Sciences 32: 521-533, 2011.


Lefkowitz, R.J.  Forward toG protein-coupled receptors: From structure to function”.  (Jesus Giraldo and Jean-Philippe Pin, Eds).  The Royal Society of Chemistry, 2011.


Lovgren, A.K., Kovacs, J.J., Xie, T., Potts, E.N., Li, Y., Foster, W.M., Liang, J., Meltzler, E.B., Jiang, D., Lefkowitz, R.J. and Noble, P.W.  β-Arrestin DeficiencyProtects Against Pulmonary fibrosis in Mice and Prevents Fibroblast Invasion of Extracellular Matrix.  Science Translational Medicine, Vol. 3, 1-10, 2011. PMCID: PMC3094726


Whalen, E., Rajagopal, S. and Lefkowitz, R.J.  The Therapeutic Potential of β-Arrestin and G protein-biased Agonists.  Trends in Molecular Medicine, Vol. 17, 126-139, 2011.


Kenakin, T., Agnati, L.F., Caron, M., Fredholm, B., Guidoli, D., Kobilka, B., Lefkowitz, R.J., Woods, A., Fuxe, K.  G protein-coupled receptors: finding the words to describe mononers, oligomers, and their molecular mechanisms and defining their meaning.  Recep. Signal Transduct. Res. 30: 284-286, 2010


Xiao, K., Sun, J., Kim, J., Rajagopal, S., Zhai, B., Villen, J., Haas, W., Kovacs, J.J., Shukla, A.K., Hara, M.R., Hernandez, M., Lachmann, A., Zhao, S., Lin, Y., Cheng, Y., Mizuno, K., Ma’ayan, A., Gygi, S.P. and Lefkowitz, R.J.  Global phosphorylation analysis of β-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).  Proc. Natl. Acad. Sci., 107, 15299-15304, 2010. PMCID: PMC2930550


Shukla, A.K., Kim, J., Ahn, S., Xiao, K., Shenoy, S.K., Liedtke, W., and Lefkowitz, R.J.  Arresting a TRP Channel - β-Arrestin1 Mediates Ubiquitination and Functional Downregulationof TRPV4. 

J. Biol. Chem. 285: 30115-30125, 2010. PMCID: PMC2943294


Rajagopal, S., Rajagopal, K., Lefkowitz, R.J.  Teaching Old receptors new tricks: biasing seven-transmembrane receptors.  Nature Reviews Drug Discovery 9, 1-12, 2010. PMCID: PMC2902265


Rajagopal, S., Kim, J., Ahn, S., Craig, S., Lam, C.M., Gerard, N.P., Gerard, C. and Lefkowitz, R.J.  β arrestin-but not G-protein-mediated signaling by the “Decoy” Receptor CXCR7. Proc. Natl. Acad. Sci. USA, 107: 628-32, 2010. PMCID: PMC2818968


Kovacs, J.J., Hara, M.R., Davenport, C.L., Kim, J. and Lefkowitz, R.J.  Arrestin Development: Emerging Roles for β-arrestins in Developmental Signaling Pathways.  Developmental Cell 17: 443-458, 2009.


Chen, M., Philipp, M., Wang, J., Premont, R.T., Garrison, T.R., Caron, M.G., Lefkowitz, R.J. and Chen, W.  G Protein-coupled Receptor Kinases Phosphorylate LRP6 in the Wnt Pathway.  J. Biol. Chem. 284: 35040-35048, 2009.


Xie, L., Xiao, K., Whalen, E.J., Forrester, M.T., Gygi, S.P., Lefkowitz, R.J. and Stamler, J.S. Oxygen-regulated b2-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation. Science Signaling 78: 1-10, 2009.


Gesty-Palmer, D., Flannery, P., Yuan, L., Corsino, L., Spurney, R., Lefkowitz, R.J. and Luttrell, L.M.  A b-Arrestin Biased Agonist of the Parathyroid Hormone Receptor (PTH1R) Promotes Bone Formation Independent of G Protein Activation.  Science Translational Medicine 1: 1-9, 2009. PMCID: PMC2852200


Zidar, D.A., Violin, J.D., Whalen, E.J. and Lefkowitz, R.J.  Selective Engagement of G protein-coupled Receptor Kinase (GRKs) encodes distinct functions of biased ligands. Proc. Natl. Acad. Sci. USA 106: 9649-9654, 2009.


Kim, J., Ahn, S., Rajagopal, K. and Lefkowitz, R.J. Independent b-Arrestin2 and Gq/PKCz Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the EGFR.  J. Biol. Chem. 284: 11953-11962, 2009.


Walters, R.W., Shukla, A.K., Kovacs, J.J., Violin, J.D., DeWire, S.M., Lam, C.M., Chen, J.R., Muehlbauer, M.J., Whalen, E.J. and Lefkowitz, R.J.  b-arresin1 Mediates nicotinic acid induced flushing, but not its antilipolytic effect.  J. Clin. Invest. 119: 1312-1321, 2009.


Shenoy, S.K., Modi, A.S., Shukla, A., Xiao, K., Berthouze, M., Ahn, S., Wilkinson, K.D., Miller, W.E. and Lefkowitz, R.J.  b-Arrestin-dependent signaling and trafficking of 7TMRs is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2.  Proc. Natl. Acad. Sci. USA 106: 6650-6655, 2009.


Ahn, S., Kim, J., Hara, M.R., Ren, X-R. and Lefkowitz, R.J.  b-Arrestin-2 Mediates Anti-Apoptotic Signaling Through Regulation of BAD Phosphorylation.  J. Biol. Chem. 284: 8855-8865, 2009.

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